Detailed information of TA system TA026781

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE(toxin)
• Location: 2010313..2010872
• Replicon: chromosome
• Accession: NC_017445
• Organism: Erwinia sp. Ejp617

Toxin (Protein)

• Gene name: parE
• Uniprot ID: E3DGW8
• Locus tag: EJP617_RS09155
• Protein ID: WP_014543380.1
• Coordinates: 2010313..2010585 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: E3DGW9
• Locus tag: EJP617_RS09160
• Protein ID: WP_014543381.1
• Coordinates: 2010582..2010872 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJP617_RS09130	2007352..2007690	+	339	WP_014542725.1	helix-turn-helix transcriptional regulator	-
EJP617_RS09135	2007776..2008114	+	339	WP_041474417.1	endoribonuclease SymE	-
EJP617_RS09140	2008164..2008664	-	501	WP_041474418.1	immunity 42 family protein	-
EJP617_RS18640	2008661..2009476	-	816	WP_071819526.1	hypothetical protein	-
EJP617_RS19990	2009453..2009689	-	237	Protein_1782	adhesin	-
EJP617_RS09155	2010313..2010585	-	273	WP_014543380.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
EJP617_RS09160	2010582..2010872	-	291	WP_014543381.1	hypothetical protein	Antitoxin
EJP617_RS09165	2010922..2011956	-	1035	WP_014543382.1	site-specific tyrosine recombinase XerC	-
EJP617_RS09170	2011986..2015021	-	3036	WP_014543383.1	toprim domain-containing protein	-
EJP617_RS09175	2015154..2015492	+	339	WP_014542725.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1999336..2019963	20627

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10490.92 Da
• Isoelectric Point: 7.3185

>T26781 WP_014543380.1 NC_017445:c2010585-2010313 [Erwinia sp. Ejp617]
MKLLWTEPARDDRRSIREYIAQDNPVAAVEMDEQLSSRANQLTEQPNIGRAGRVAGTRELVVHRHYIVIYDVVAEEVQIL
RVLHTSRRWP

Nucleotide

• Length: 273 bp

>T26781 NC_017445:c2010585-2010313 [Erwinia sp. Ejp617]
ATGAAGTTACTATGGACAGAACCCGCCAGGGATGACCGCAGATCGATCCGTGAATATATCGCGCAGGATAATCCTGTTGC
AGCAGTTGAGATGGATGAACAACTGTCATCCAGAGCAAACCAGCTTACGGAACAACCTAATATCGGGCGGGCGGGCCGCG
TGGCAGGTACGCGGGAACTGGTCGTCCATCGGCATTACATCGTTATCTATGATGTAGTGGCAGAAGAAGTGCAGATACTC
CGGGTGCTGCACACTTCCAGACGCTGGCCATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10878.23 Da
• Isoelectric Point: 5.2706

>AT26781 WP_014543381.1 NC_017445:c2010872-2010582 [Erwinia sp. Ejp617]
MREATFTFRVDETLKSEFTTAAKACDRTGAQLIRDFMREFIKKEQEAAEYDQWFRQKVEAGRAAVAQGRVISAEEVEAEA
AEWRKNLLSGGTTGKL

Nucleotide

• Length: 291 bp

>AT26781 NC_017445:c2010872-2010582 [Erwinia sp. Ejp617]
ATGCGCGAAGCCACCTTTACCTTCCGCGTTGATGAGACGCTAAAATCTGAATTTACCACAGCAGCAAAGGCCTGTGACCG
TACAGGTGCCCAGCTGATCCGCGACTTCATGAGGGAGTTCATTAAAAAAGAACAGGAAGCGGCAGAATATGACCAGTGGT
TCCGCCAGAAAGTTGAGGCGGGACGGGCCGCAGTTGCTCAGGGGCGAGTGATATCAGCAGAAGAGGTTGAAGCTGAAGCA
GCAGAATGGAGAAAAAATCTCCTCAGCGGAGGAACTACCGGAAAACTATGA

Structures

Toxin

• AlphaFold DB: E3DGW8

Antitoxin

• AlphaFold DB: E3DGW9