Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 2275..2822 Replicon plasmid pDETEC78
Accession NZ_CP116073
Organism Escherichia coli strain DETEC-S589

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag PIC30_RS26565 Protein ID WP_001384452.1
Coordinates 2544..2822 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0S0ZPX5
Locus tag PIC30_RS26560 Protein ID WP_032291093.1
Coordinates 2275..2544 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC30_RS26550 (PIC30_26550) 495..1367 + 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
PIC30_RS26555 (PIC30_26555) 2062..2220 + 159 WP_271287429.1 hypothetical protein -
PIC30_RS26560 (PIC30_26560) 2275..2544 + 270 WP_032291093.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PIC30_RS26565 (PIC30_26565) 2544..2822 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
PIC30_RS26570 (PIC30_26570) 2862..3710 + 849 WP_032291092.1 3'-5' exonuclease -
PIC30_RS26575 (PIC30_26575) 4026..4535 - 510 WP_032291091.1 hypothetical protein -
PIC30_RS26580 (PIC30_26580) 4591..5193 - 603 WP_032291854.1 ProQ/FINO family protein -
PIC30_RS26585 (PIC30_26585) 5546..6892 + 1347 WP_001132021.1 protein YagA -
PIC30_RS26590 (PIC30_26590) 7427..7729 - 303 WP_001245884.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 - 1..89022 89022


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T267809 WP_001384452.1 NZ_CP116073:2544-2822 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10069.43 Da        Isoelectric Point: 8.0565

>AT267809 WP_032291093.1 NZ_CP116073:2275-2544 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLGCGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A0S0ZPX5

References