Detailed information of TA system TA026780

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1976974..1977634
• Replicon: chromosome
• Accession: NC_017445
• Organism: Erwinia sp. Ejp617

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: E3DGD5
• Locus tag: EJP617_RS09000
• Protein ID: WP_014543353.1
• Coordinates: 1977221..1977634 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: E3DGD4
• Locus tag: EJP617_RS08995
• Protein ID: WP_014543352.1
• Coordinates: 1976974..1977240 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJP617_RS08975	1973449..1974192	+	744	WP_014543347.1	SDR family oxidoreductase	-
EJP617_RS08980	1974280..1974888	-	609	WP_014543348.1	HD domain-containing protein	-
EJP617_RS08985	1975102..1975761	+	660	WP_014543349.1	hemolysin III family protein	-
EJP617_RS08990	1975762..1976748	-	987	WP_014543350.1	tRNA-modifying protein YgfZ	-
EJP617_RS08995	1976974..1977240	+	267	WP_014543352.1	FAD assembly factor SdhE	Antitoxin
EJP617_RS09000	1977221..1977634	+	414	WP_014543353.1	hypothetical protein	Toxin
EJP617_RS09005	1977758..1978276	-	519	WP_014543354.1	flavodoxin FldB	-
EJP617_RS09010	1978322..1979275	-	954	WP_014543355.1	DMT family transporter	-
EJP617_RS09015	1979552..1980445	+	894	WP_014543356.1	site-specific tyrosine recombinase XerD	-
EJP617_RS09020	1980491..1981195	+	705	WP_014543357.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-130)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16072.05 Da
• Isoelectric Point: 12.2998

>T26780 WP_014543353.1 NC_017445:1977221-1977634 [Erwinia sp. Ejp617]
VALWQCELRQSKLAQRLSLLLHGAVMLALLLPAWPASSGLVRMLSLVLVLLECIRSRRRIRRRRGDVALLTGSVVRWRQR
QWQILSRPWLTRQAILLSLHDAKGKRERLWLFADSMEDSDWRRLRMQLLNNKEQGNG

Nucleotide

• Length: 414 bp

>T26780 NC_017445:1977221-1977634 [Erwinia sp. Ejp617]
GTGGCCCTGTGGCAATGTGAACTGCGGCAATCAAAGCTGGCACAGCGGCTTTCGCTGCTGCTGCATGGGGCAGTGATGCT
GGCGCTGCTACTGCCTGCATGGCCCGCCAGCTCTGGCCTGGTGCGGATGCTGTCGCTGGTTTTGGTACTGCTGGAGTGCA
TACGCAGCCGGCGGCGCATTCGCCGCCGCCGGGGTGATGTCGCTTTGTTGACGGGGTCGGTTGTACGCTGGCGTCAGCGT
CAGTGGCAGATCCTTTCCCGCCCGTGGCTGACCCGGCAGGCAATCCTGCTGTCACTGCATGATGCTAAGGGGAAGCGTGA
ACGGCTGTGGCTGTTCGCCGACAGCATGGAAGACAGTGACTGGCGTCGGTTACGTATGCAGTTGCTGAACAATAAGGAGC
AGGGGAATGGATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10540.11 Da
• Isoelectric Point: 5.6964

>AT26780 WP_014543352.1 NC_017445:1976974-1977240 [Erwinia sp. Ejp617]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDDDKRLFVRLLESDDPDLFNWLMNHGEPADAELKRMVLLIQQRN
KQRGPVAM

Nucleotide

• Length: 267 bp

>AT26780 NC_017445:1976974-1977240 [Erwinia sp. Ejp617]
ATGGATATTACTAATAAATCACGTATTCACTGGGCATGCCGTCGCGGCATGCGCGAACTGGATATCTCGATCATGCCGTT
TTTTCAGTACGAGTTTGACTCGCTGAACGATGACGATAAGCGTCTGTTTGTCCGCCTGCTGGAGAGCGACGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGAGAGCCGGCAGATGCAGAGCTGAAAAGGATGGTGTTGCTTATCCAGCAGAGAAAT
AAACAACGTGGCCCTGTGGCAATGTGA

Structures

Toxin

• AlphaFold DB: E3DGD5

Antitoxin

• AlphaFold DB: E3DGD4