Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4821703..4822628 Replicon chromosome
Accession NZ_CP116071
Organism Escherichia coli strain DETEC-S589

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag PIC30_RS23930 Protein ID WP_014640052.1
Coordinates 4821703..4822089 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag PIC30_RS23935 Protein ID WP_024174200.1
Coordinates 4822119..4822628 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC30_RS23875 (4816751) 4816751..4817113 + 363 WP_000135680.1 protein YfdP -
PIC30_RS23880 (4817179) 4817179..4818003 + 825 WP_000081287.1 DUF2303 family protein -
PIC30_RS23885 (4818131) 4818131..4818667 + 537 WP_032340541.1 5'-deoxynucleotidase -
PIC30_RS23890 (4818658) 4818658..4819008 + 351 WP_032340539.1 hypothetical protein -
PIC30_RS23895 (4819005) 4819005..4819604 + 600 WP_032340538.1 ead/Ea22-like family protein -
PIC30_RS23900 (4819606) 4819606..4819797 + 192 WP_016236813.1 hypothetical protein -
PIC30_RS23905 (4819800) 4819800..4820114 + 315 Protein_4686 DUF551 domain-containing protein -
PIC30_RS23910 (4820361) 4820361..4820552 + 192 WP_229430275.1 DUF551 domain-containing protein -
PIC30_RS23915 (4820552) 4820552..4821124 + 573 WP_001061345.1 3'-5' exonuclease -
PIC30_RS23920 (4821161) 4821161..4821442 + 282 WP_001093916.1 pyocin activator PrtN family protein -
PIC30_RS23925 (4821490) 4821490..4821663 - 174 WP_000390072.1 hypothetical protein -
PIC30_RS23930 (4821703) 4821703..4822089 - 387 WP_014640052.1 hypothetical protein Toxin
PIC30_RS23935 (4822119) 4822119..4822628 - 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
PIC30_RS23940 (4823162) 4823162..4823677 + 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
PIC30_RS23945 (4823719) 4823719..4823928 - 210 WP_001296638.1 CsbD family protein -
PIC30_RS23950 (4824044) 4824044..4825369 - 1326 WP_001296637.1 MATE family efflux transporter DinF -
PIC30_RS23955 (4825442) 4825442..4826050 - 609 WP_000646078.1 transcriptional repressor LexA -
PIC30_RS23960 (4826160) 4826160..4826528 - 369 WP_000002899.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4781501..4829122 47621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T267799 WP_014640052.1 NZ_CP116071:c4822089-4821703 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT267799 WP_024174200.1 NZ_CP116071:c4822628-4822119 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References