Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3787535..3788153 Replicon chromosome
Accession NZ_CP116071
Organism Escherichia coli strain DETEC-S589

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC30_RS19000 Protein ID WP_001291435.1
Coordinates 3787935..3788153 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC30_RS18995 Protein ID WP_000344800.1
Coordinates 3787535..3787909 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC30_RS18985 (3782625) 3782625..3783818 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PIC30_RS18990 (3783841) 3783841..3786990 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PIC30_RS18995 (3787535) 3787535..3787909 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC30_RS19000 (3787935) 3787935..3788153 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC30_RS19005 (3788327) 3788327..3788878 + 552 WP_000102543.1 maltose O-acetyltransferase -
PIC30_RS19010 (3788994) 3788994..3789464 + 471 WP_000136192.1 YlaC family protein -
PIC30_RS19015 (3789628) 3789628..3791178 + 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC30_RS19020 (3791220) 3791220..3791573 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PIC30_RS19030 (3791952) 3791952..3792263 + 312 WP_000409908.1 MGMT family protein -
PIC30_RS19035 (3792294) 3792294..3792866 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T267794 WP_001291435.1 NZ_CP116071:3787935-3788153 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT267794 WP_000344800.1 NZ_CP116071:3787535-3787909 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References