Detailed information of TA system TA026779

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1444850..1445484
• Replicon: chromosome
• Accession: NC_017445
• Organism: Erwinia sp. Ejp617

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EJP617_RS06555
• Protein ID: WP_014542955.1
• Coordinates: 1444850..1445254 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: E3DCE6
• Locus tag: EJP617_RS06560
• Protein ID: WP_012439902.1
• Coordinates: 1445254..1445484 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJP617_RS06540	1440041..1441201	+	1161	WP_014542952.1	cystathionine gamma-synthase	-
EJP617_RS06545	1441204..1443639	+	2436	WP_014542953.1	bifunctional aspartate kinase/homoserine dehydrogenase II	-
EJP617_RS06550	1443898..1444809	+	912	WP_012666536.1	methylenetetrahydrofolate reductase	-
EJP617_RS06555	1444850..1445254	-	405	WP_014542955.1	tRNA(fMet)-specific endonuclease VapC	Toxin
EJP617_RS06560	1445254..1445484	-	231	WP_012439902.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
EJP617_RS06565	1445656..1448307	-	2652	WP_014542956.1	phosphoenolpyruvate carboxylase	-
EJP617_RS06570	1448553..1449704	-	1152	WP_014542957.1	acetylornithine deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15071.53 Da
• Isoelectric Point: 7.7459

>T26779 WP_014542955.1 NC_017445:c1445254-1444850 [Erwinia sp. Ejp617]
MLKFMLDTNICIFTIKNKPPMVRETFVSYYGQLCISSITLMELVYGAEKSSNPRQNLDVIEGFCARLEILPYAEAAATHS
GQLRAELAKKGTPIGPWDVMIAGHARSQGLILVTNNLREFERVPGLRLEDWANR

Nucleotide

• Length: 405 bp

>T26779 NC_017445:c1445254-1444850 [Erwinia sp. Ejp617]
ATGCTGAAATTCATGCTGGACACCAATATCTGCATCTTCACCATCAAAAACAAGCCACCCATGGTCAGGGAAACATTTGT
GTCGTACTACGGTCAACTGTGCATCAGCAGCATTACGCTGATGGAGCTGGTTTACGGTGCAGAAAAATCAAGCAACCCCA
GGCAGAATCTGGATGTGATTGAAGGTTTCTGCGCAAGGCTGGAAATTCTCCCTTATGCAGAAGCTGCCGCCACTCATAGC
GGGCAACTCCGCGCCGAGTTGGCCAAAAAGGGCACCCCGATTGGCCCCTGGGACGTCATGATAGCGGGACATGCGCGTTC
GCAAGGCCTGATACTGGTCACCAACAACCTGCGTGAGTTTGAGCGCGTTCCGGGTCTGCGCCTGGAGGACTGGGCCAACC
GTTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8805.88 Da
• Isoelectric Point: 4.7961

>AT26779 WP_012439902.1 NC_017445:c1445484-1445254 [Erwinia sp. Ejp617]
MEKTTVFKNNRSQAVRLPKALALPEDVKCVDIIAIGRTRIISPVGESWDNWFDGENVTADFMDDREQPSEQRREHF

Nucleotide

• Length: 231 bp

>AT26779 NC_017445:c1445484-1445254 [Erwinia sp. Ejp617]
ATGGAAAAAACCACCGTTTTTAAAAACAACCGCTCACAGGCGGTGCGCCTGCCCAAAGCCCTGGCACTACCGGAAGATGT
TAAGTGCGTTGATATTATTGCCATTGGCCGCACGCGCATTATATCGCCAGTAGGTGAAAGCTGGGATAACTGGTTTGATG
GTGAAAATGTCACGGCTGACTTTATGGACGACCGTGAACAACCTTCAGAGCAGAGGCGAGAACATTTCTGA

Structures

Antitoxin

• AlphaFold DB: E3DCE6