Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2565754..2567342 Replicon chromosome
Accession NZ_CP116071
Organism Escherichia coli strain DETEC-S589

Toxin (Protein)


Gene name hipA Uniprot ID B7MMY1
Locus tag PIC30_RS12645 Protein ID WP_001125475.1
Coordinates 2566020..2567342 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PIC30_RS12640 Protein ID WP_001332145.1
Coordinates 2565754..2566020 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC30_RS12625 (2562122) 2562122..2563573 + 1452 WP_000854637.1 tagaturonate reductase -
PIC30_RS12630 (2563770) 2563770..2564684 + 915 WP_001306069.1 bestrophin family protein -
PIC30_RS12635 (2564688) 2564688..2565446 - 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
PIC30_RS12640 (2565754) 2565754..2566020 + 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PIC30_RS12645 (2566020) 2566020..2567342 + 1323 WP_001125475.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
PIC30_RS12650 (2567652) 2567652..2567834 - 183 Protein_2477 hypothetical protein -
PIC30_RS12655 (2567968) 2567968..2568750 + 783 WP_001221834.1 SDR family oxidoreductase -
PIC30_RS12660 (2568994) 2568994..2569101 - 108 Protein_2479 hypothetical protein -
PIC30_RS12665 (2569526) 2569526..2569720 + 195 Protein_2480 fimbrial protein -
PIC30_RS12670 (2569694) 2569694..2570392 + 699 WP_166709565.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49426.24 Da        Isoelectric Point: 8.9380

>T267788 WP_001125475.1 NZ_CP116071:2566020-2567342 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT267788 WP_001332145.1 NZ_CP116071:2565754-2566020 [Escherichia coli]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L5M8

Antitoxin

Source ID Structure

References