Detailed information of TA system TA026778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1355245..1355822
• Replicon: chromosome
• Accession: NC_017445
• Organism: Erwinia sp. Ejp617

Toxin (Protein)

• Gene name: parE
• Uniprot ID: E3DB51
• Locus tag: EJP617_RS06080
• Protein ID: WP_014542885.1
• Coordinates: 1355511..1355822 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E3DB50
• Locus tag: EJP617_RS06075
• Protein ID: WP_014542884.1
• Coordinates: 1355245..1355523 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJP617_RS06050	1350880..1351497	-	618	WP_014542881.1	trimeric intracellular cation channel family protein	-
EJP617_RS06055	1351963..1352607	+	645	WP_012666437.1	response regulator transcription factor	-
EJP617_RS06060	1352683..1352943	+	261	WP_168371128.1	hypothetical protein	-
EJP617_RS06065	1352960..1354324	-	1365	WP_014542883.1	MFS transporter	-
EJP617_RS06070	1354487..1354825	-	339	WP_004167784.1	alkylphosphonate utilization protein	-
EJP617_RS06075	1355245..1355523	+	279	WP_014542884.1	CopG family ribbon-helix-helix protein	Antitoxin
EJP617_RS06080	1355511..1355822	+	312	WP_014542885.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EJP617_RS19680	1356675..1356824	+	150	WP_168371104.1	hypothetical protein	-
EJP617_RS19325	1357067..1358244	+	1178	WP_168371118.1	IS3 family transposase	-
EJP617_RS19970	1358298..1358441	-	144	WP_193353791.1	hypothetical protein	-
EJP617_RS19330	1358770..1359614	+	845	Protein_1203	IS5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-96)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11900.81 Da
• Isoelectric Point: 9.8946

>T26778 WP_014542885.1 NC_017445:1355511-1355822 [Erwinia sp. Ejp617]
MPQVIVSALAQRDLQRLQDFLKTKNRLAARKAGEVIIRAIQQLRTQPDMGRPVSLLPLEYQELVIGFGDSGYMMLYRHDR
ETDRIVILTVRHQKEAGYHGLQE

Nucleotide

• Length: 312 bp

>T26778 NC_017445:1355511-1355822 [Erwinia sp. Ejp617]
ATGCCACAGGTAATTGTCTCCGCACTGGCACAGCGGGATTTACAGCGCCTGCAGGACTTTCTCAAAACCAAAAACCGATT
GGCGGCCAGAAAAGCCGGTGAAGTGATCATCCGGGCTATCCAACAGCTGAGAACGCAGCCGGACATGGGTCGCCCGGTTT
CTCTTCTCCCACTGGAATACCAGGAACTGGTGATCGGATTTGGCGACAGTGGTTATATGATGCTCTATCGCCACGACCGG
GAAACGGACCGGATAGTGATCCTGACAGTCCGGCACCAAAAAGAAGCCGGCTATCACGGCCTGCAGGAATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10721.74 Da
• Isoelectric Point: 4.6216

>AT26778 WP_014542884.1 NC_017445:1355245-1355523 [Erwinia sp. Ejp617]
MSAATSIRLDDELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLSAEEVEAWIDTWG
TENEQDAPPCHR

Nucleotide

• Length: 279 bp

>AT26778 NC_017445:1355245-1355523 [Erwinia sp. Ejp617]
ATGTCAGCAGCAACATCCATCAGGCTTGATGATGAACTCAAAGACCGCCTGAAAACCCTTGCCGATGACCGCCATCGCTC
CGCCCATGCTCTGATGCTGGAAGCGATCACCGAATACATCGACCGGGAAGAAAAGCGCAGCCAGTACCTGAGGGATGGAC
AGGCCGCATGGCAGCACTATCAGGAAACCGGTCTGCACCTGAGCGCCGAAGAGGTGGAAGCGTGGATAGATACCTGGGGA
ACTGAGAATGAGCAGGATGCTCCACCATGCCACAGGTAA

Structures

Toxin

• AlphaFold DB: E3DB51

Antitoxin

• AlphaFold DB: E3DB50