Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 885506..886160 Replicon chromosome
Accession NZ_CP116071
Organism Escherichia coli strain DETEC-S589

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag PIC30_RS04350 Protein ID WP_000244781.1
Coordinates 885753..886160 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PIC30_RS04345 Protein ID WP_000354046.1
Coordinates 885506..885772 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC30_RS04325 (881594) 881594..883027 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
PIC30_RS04330 (883072) 883072..883383 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
PIC30_RS04335 (883547) 883547..884206 + 660 WP_000250274.1 hemolysin III family protein -
PIC30_RS04340 (884283) 884283..885263 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
PIC30_RS04345 (885506) 885506..885772 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PIC30_RS04350 (885753) 885753..886160 + 408 WP_000244781.1 protein YgfX Toxin
PIC30_RS04355 (886200) 886200..886721 - 522 WP_001055874.1 flavodoxin FldB -
PIC30_RS04360 (886833) 886833..887729 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
PIC30_RS04365 (887754) 887754..888464 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PIC30_RS04370 (888470) 888470..890203 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T267777 WP_000244781.1 NZ_CP116071:885753-886160 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT267777 WP_000354046.1 NZ_CP116071:885506-885772 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References