Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 12041..12588 Replicon plasmid pDETEC45
Accession NZ_CP116070
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag PID00_RS27785 Protein ID WP_001384452.1
Coordinates 12310..12588 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID B7LIH2
Locus tag PID00_RS27780 Protein ID WP_012605119.1
Coordinates 12041..12310 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS27755 (PID00_27750) 8518..9222 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
PID00_RS27760 (PID00_27755) 9234..9557 - 324 Protein_12 recombinase family protein -
PID00_RS27765 (PID00_27760) 9658..10354 + 697 WP_094110542.1 IS1 family transposase -
PID00_RS27770 (PID00_27765) 10399..10902 - 504 WP_016232763.1 hypothetical protein -
PID00_RS27775 (PID00_27770) 11092..11796 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
PID00_RS27780 (PID00_27775) 12041..12310 + 270 WP_012605119.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PID00_RS27785 (PID00_27780) 12310..12588 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
PID00_RS27790 (PID00_27785) 12623..12781 + 159 Protein_18 3'-5' exonuclease -
PID00_RS27795 (PID00_27790) 13062..13514 + 453 WP_271290629.1 acyltransferase -
PID00_RS27800 (PID00_27795) 13565..14839 - 1275 Protein_20 Tn3 family transposase -
PID00_RS27805 (PID00_27800) 14945..16101 + 1157 WP_096122008.1 IS3-like element IS600 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..81965 81965
- inside IScluster/Tn - - 8518..18567 10049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T267775 WP_001384452.1 NZ_CP116070:12310-12588 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10200.51 Da        Isoelectric Point: 8.8735

>AT267775 WP_012605119.1 NZ_CP116070:12041-12310 [Escherichia coli]
MTQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDVLSHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A0A0GNA3

References