Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2324..2859 Replicon plasmid pDETEC45
Accession NZ_CP116070
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name relE Uniprot ID B7LIF2
Locus tag PID00_RS27710 Protein ID WP_001536606.1
Coordinates 2572..2859 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag PID00_RS27705 Protein ID WP_001132900.1
Coordinates 2324..2575 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS27700 (PID00_27695) 495..1367 + 873 WP_016232756.1 incFII family plasmid replication initiator RepA -
PID00_RS27705 (PID00_27700) 2324..2575 + 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PID00_RS27710 (PID00_27705) 2572..2859 + 288 WP_001536606.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PID00_RS27715 (PID00_27710) 2963..3553 + 591 WP_001536605.1 serine acetyltransferase -
PID00_RS27720 (PID00_27715) 3656..4309 + 654 WP_016238163.1 ProQ/FINO family protein -
PID00_RS27725 (PID00_27720) 4377..4691 + 315 WP_016238162.1 hypothetical protein -
PID00_RS27730 (PID00_27725) 4938..5078 - 141 WP_001536601.1 colicin release lysis protein -
PID00_RS27735 (PID00_27730) 5176..5505 - 330 WP_000182536.1 colicin transporter -
PID00_RS27740 (PID00_27735) 5495..5755 - 261 WP_225374575.1 colicin E5-related ribonuclease -
PID00_RS27745 (PID00_27740) 6132..6998 - 867 WP_001536599.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..81965 81965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11086.10 Da        Isoelectric Point: 10.4712

>T267774 WP_001536606.1 NZ_CP116070:2572-2859 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
REHSNVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT267774 WP_001132900.1 NZ_CP116070:2324-2575 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4PMB7

Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References