Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 86081..86603 Replicon plasmid pDETEC43
Accession NZ_CP116068
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name relE Uniprot ID S1PVW2
Locus tag PID00_RS27115 Protein ID WP_001681795.1
Coordinates 86322..86603 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1Q9V6
Locus tag PID00_RS27110 Protein ID WP_001681796.1
Coordinates 86081..86332 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS27085 (PID00_27080) 81497..82204 - 708 WP_001114349.1 A24 family peptidase -
PID00_RS27090 (PID00_27085) 82164..82646 - 483 WP_048967178.1 lytic transglycosylase domain-containing protein -
PID00_RS27095 (PID00_27090) 82694..83230 - 537 WP_001011500.1 type 4 pilus major pilin -
PID00_RS27100 (PID00_27095) 83280..84380 - 1101 WP_001211427.1 type II secretion system F family protein -
PID00_RS27105 (PID00_27100) 84382..85890 - 1509 WP_108451519.1 ATPase, T2SS/T4P/T4SS family -
PID00_RS27110 (PID00_27105) 86081..86332 + 252 WP_001681796.1 hypothetical protein Antitoxin
PID00_RS27115 (PID00_27110) 86322..86603 + 282 WP_001681795.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PID00_RS27120 (PID00_27115) 86913..87365 - 453 WP_001681794.1 type IV pilus biogenesis protein PilP -
PID00_RS27125 (PID00_27120) 87355..88650 - 1296 WP_001681793.1 type 4b pilus protein PilO2 -
PID00_RS27130 (PID00_27125) 88671..90290 - 1620 WP_001681792.1 PilN family type IVB pilus formation outer membrane protein -
PID00_RS27135 (PID00_27130) 90321..90758 - 438 WP_001681791.1 type IV pilus biogenesis protein PilM -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..98708 98708


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-86)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 11122.01 Da        Isoelectric Point: 10.6249

>T267772 WP_001681795.1 NZ_CP116068:86322-86603 [Escherichia coli]
MTYELEFERRALKEWHKLGHTVREQFKKKLSERLKNPRVPAARLHGHTDRYKIKLRASGYRLVYQVIDEKIVLLVIAVGK
RESSEVYQMADIR

Download         Length: 282 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9124.33 Da        Isoelectric Point: 4.0610

>AT267772 WP_001681796.1 NZ_CP116068:86081-86332 [Escherichia coli]
MSYQILTTTAASITELKKNPMGTVAEGEGGAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVKVSL
DDL

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PVW2


Antitoxin

Source ID Structure
AlphaFold DB S1Q9V6

References