Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 5253058..5253763 Replicon chromosome
Accession NZ_CP116067
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag PID00_RS25990 Protein ID WP_000539521.1
Coordinates 5253377..5253763 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PID00_RS25985 Protein ID WP_001280945.1
Coordinates 5253058..5253387 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS25970 (5248215) 5248215..5249126 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
PID00_RS25975 (5249304) 5249304..5251652 + 2349 WP_042102082.1 EAL domain-containing protein -
PID00_RS25980 (5251660) 5251660..5252988 + 1329 WP_000086919.1 GGDEF domain-containing protein -
PID00_RS25985 (5253058) 5253058..5253387 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
PID00_RS25990 (5253377) 5253377..5253763 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PID00_RS25995 (5253989) 5253989..5255314 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
PID00_RS26000 (5255527) 5255527..5255910 + 384 WP_000497137.1 biofilm formation regulator BssR -
PID00_RS26005 (5256021) 5256021..5257136 + 1116 WP_271290524.1 aldose sugar dehydrogenase YliI -
PID00_RS26010 (5257133) 5257133..5257759 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T267770 WP_000539521.1 NZ_CP116067:c5253763-5253377 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT267770 WP_001280945.1 NZ_CP116067:c5253387-5253058 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References