Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4810511..4811129 Replicon chromosome
Accession NZ_CP116067
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PID00_RS23800 Protein ID WP_001291435.1
Coordinates 4810511..4810729 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PID00_RS23805 Protein ID WP_000344800.1
Coordinates 4810755..4811129 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS23765 (4805799) 4805799..4806371 + 573 WP_000779831.1 YbaY family lipoprotein -
PID00_RS23770 (4806402) 4806402..4806713 - 312 WP_000409911.1 MGMT family protein -
PID00_RS23780 (4807092) 4807092..4807445 + 354 WP_000878140.1 DUF1428 domain-containing protein -
PID00_RS23785 (4807487) 4807487..4809037 - 1551 WP_271290509.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PID00_RS23790 (4809201) 4809201..4809671 - 471 WP_000136192.1 YlaC family protein -
PID00_RS23795 (4809787) 4809787..4810338 - 552 WP_000102539.1 maltose O-acetyltransferase -
PID00_RS23800 (4810511) 4810511..4810729 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PID00_RS23805 (4810755) 4810755..4811129 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PID00_RS23810 (4811675) 4811675..4814824 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
PID00_RS23815 (4814847) 4814847..4816040 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T267768 WP_001291435.1 NZ_CP116067:c4810729-4810511 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT267768 WP_000344800.1 NZ_CP116067:c4811129-4810755 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References