Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3892901..3893398 Replicon chromosome
Accession NZ_CP116067
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PID00_RS19270 Protein ID WP_001173343.1
Coordinates 3893225..3893398 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A1V2FLJ5
Locus tag PID00_RS19265 Protein ID WP_001317561.1
Coordinates 3892901..3893197 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS19255 (3888257) 3888257..3892186 + 3930 WP_096122463.1 autotransporter outer membrane beta-barrel domain-containing protein -
PID00_RS19260 (3892400) 3892400..3892672 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
PID00_RS19265 (3892901) 3892901..3893197 + 297 WP_001317561.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PID00_RS19270 (3893225) 3893225..3893398 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PID00_RS19275 (3893517) 3893517..3895034 - 1518 WP_000003806.1 lysine--tRNA ligase -
PID00_RS19280 (3895271) 3895271..3896728 - 1458 WP_104274718.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3877295..3902252 24957


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T267765 WP_001173343.1 NZ_CP116067:3893225-3893398 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT267765 WP_001317561.1 NZ_CP116067:3892901-3893197 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMSFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2FLJ5

References