Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2418016..2418670 Replicon chromosome
Accession NZ_CP116067
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag PID00_RS12230 Protein ID WP_000244781.1
Coordinates 2418016..2418423 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PID00_RS12235 Protein ID WP_000354046.1
Coordinates 2418404..2418670 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS12210 (2413974) 2413974..2415707 - 1734 WP_096121758.1 single-stranded-DNA-specific exonuclease RecJ -
PID00_RS12215 (2415713) 2415713..2416423 - 711 WP_096121757.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PID00_RS12220 (2416447) 2416447..2417343 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PID00_RS12225 (2417455) 2417455..2417976 + 522 WP_075335445.1 flavodoxin FldB -
PID00_RS12230 (2418016) 2418016..2418423 - 408 WP_000244781.1 protein YgfX Toxin
PID00_RS12235 (2418404) 2418404..2418670 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PID00_RS12240 (2418923) 2418923..2419903 + 981 WP_001562036.1 tRNA-modifying protein YgfZ -
PID00_RS12245 (2419980) 2419980..2420639 - 660 WP_000250269.1 hemolysin III family protein -
PID00_RS12250 (2420803) 2420803..2421114 - 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
PID00_RS12255 (2421159) 2421159..2422592 + 1434 WP_001562037.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T267758 WP_000244781.1 NZ_CP116067:c2418423-2418016 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT267758 WP_000354046.1 NZ_CP116067:c2418670-2418404 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References