Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2257098..2257681 Replicon chromosome
Accession NZ_CP116067
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name mazF Uniprot ID V0SV58
Locus tag PID00_RS11575 Protein ID WP_000254750.1
Coordinates 2257098..2257433 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag PID00_RS11580 Protein ID WP_000581937.1
Coordinates 2257433..2257681 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS11555 (2252104) 2252104..2252925 + 822 WP_271290605.1 YgcG family protein -
PID00_RS11560 (2252985) 2252985..2254283 - 1299 WP_000036723.1 phosphopyruvate hydratase -
PID00_RS11565 (2254370) 2254370..2256007 - 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
PID00_RS11570 (2256235) 2256235..2257026 - 792 WP_096122425.1 nucleoside triphosphate pyrophosphohydrolase -
PID00_RS11575 (2257098) 2257098..2257433 - 336 WP_000254750.1 endoribonuclease MazF Toxin
PID00_RS11580 (2257433) 2257433..2257681 - 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PID00_RS11585 (2257759) 2257759..2259993 - 2235 WP_000226815.1 GTP pyrophosphokinase -
PID00_RS11590 (2260041) 2260041..2261342 - 1302 WP_001561958.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12067.95 Da        Isoelectric Point: 8.2618

>T267757 WP_000254750.1 NZ_CP116067:c2257433-2257098 [Escherichia coli]
MVSRYVPDTGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT267757 WP_000581937.1 NZ_CP116067:c2257681-2257433 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SV58

Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References