Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1952596..1953221 Replicon chromosome
Accession NZ_CP116067
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag PID00_RS10130 Protein ID WP_000911329.1
Coordinates 1952596..1952994 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PID00_RS10135 Protein ID WP_000450524.1
Coordinates 1952994..1953221 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS10110 (1948503) 1948503..1948703 + 201 WP_000383836.1 YpfN family protein -
PID00_RS10115 (1948784) 1948784..1949482 - 699 WP_000679819.1 esterase -
PID00_RS10120 (1949556) 1949556..1951571 - 2016 WP_096122032.1 tRNA cytosine(34) acetyltransferase TmcA -
PID00_RS10125 (1951586) 1951586..1952449 - 864 WP_001267498.1 neutral zinc metallopeptidase -
PID00_RS10130 (1952596) 1952596..1952994 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
PID00_RS10135 (1952994) 1952994..1953221 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PID00_RS10140 (1953377) 1953377..1954090 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PID00_RS10145 (1954303) 1954303..1955337 - 1035 WP_001296286.1 outer membrane protein assembly factor BamC -
PID00_RS10150 (1955354) 1955354..1956232 - 879 WP_001418108.1 4-hydroxy-tetrahydrodipicolinate synthase -
PID00_RS10155 (1956378) 1956378..1956950 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PID00_RS10160 (1956950) 1956950..1957420 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T267756 WP_000911329.1 NZ_CP116067:c1952994-1952596 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT267756 WP_000450524.1 NZ_CP116067:c1953221-1952994 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References