Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 717959..719541 Replicon chromosome
Accession NZ_CP116067
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PID00_RS03590 Protein ID WP_096122074.1
Coordinates 717959..719275 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PID00_RS03595 Protein ID WP_001296726.1
Coordinates 719275..719541 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS03575 (714449) 714449..714577 - 129 Protein_705 fimbrial protein -
PID00_RS03580 (714619) 714619..715149 - 531 WP_000876770.1 fimbrial protein -
PID00_RS03585 (715163) 715163..717790 - 2628 WP_261577323.1 fimbria/pilus outer membrane usher protein -
PID00_RS03590 (717959) 717959..719275 - 1317 WP_096122074.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
PID00_RS03595 (719275) 719275..719541 - 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PID00_RS03600 (719734) 719734..721623 - 1890 Protein_710 autotransporter barrel domain-containing lipoprotein -
PID00_RS03605 (721773) 721773..723365 - 1593 WP_096122075.1 autoinducer-2 kinase -
PID00_RS03610 (723444) 723444..724397 - 954 WP_000154356.1 transcriptional regulator LsrR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49248.84 Da        Isoelectric Point: 9.1205

>T267749 WP_096122074.1 NZ_CP116067:c719275-717959 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPSGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQENMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPQVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREWY

Download         Length: 1317 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT267749 WP_001296726.1 NZ_CP116067:c719541-719275 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References