Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 641513..642149 Replicon chromosome
Accession NZ_CP116067
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name hicA Uniprot ID A0A5F1EUB3
Locus tag PID00_RS03280 Protein ID WP_000813796.1
Coordinates 641513..641689 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PID00_RS03285 Protein ID WP_076838470.1
Coordinates 641733..642149 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS03260 (637135) 637135..638307 - 1173 WP_249542485.1 BenE family transporter YdcO -
PID00_RS03265 (638399) 638399..638935 + 537 WP_096122367.1 DNA-binding transcriptional regulator SutR -
PID00_RS03270 (639008) 639008..640969 + 1962 WP_001317809.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PID00_RS03275 (641061) 641061..641291 - 231 WP_024196315.1 DUF2554 family protein -
PID00_RS03280 (641513) 641513..641689 + 177 WP_000813796.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PID00_RS03285 (641733) 641733..642149 + 417 WP_076838470.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PID00_RS03290 (642228) 642228..643634 + 1407 WP_000760605.1 PLP-dependent aminotransferase family protein -
PID00_RS03295 (643879) 643879..645024 + 1146 WP_001563335.1 ABC transporter substrate-binding protein -
PID00_RS03300 (645042) 645042..646055 + 1014 WP_096122366.1 ABC transporter ATP-binding protein -
PID00_RS03305 (646056) 646056..646997 + 942 WP_053290975.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T267748 WP_000813796.1 NZ_CP116067:641513-641689 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLN

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15219.59 Da        Isoelectric Point: 4.5908

>AT267748 WP_076838470.1 NZ_CP116067:641733-642149 [Escherichia coli]
MRYPVTLTPAPEGGYVVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5F1EUB3

Antitoxin

Source ID Structure

References