Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 259776..260560 Replicon chromosome
Accession NZ_CP116067
Organism Escherichia coli strain DETEC-S792

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag PID00_RS01240 Protein ID WP_000613624.1
Coordinates 259776..260270 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B1LI61
Locus tag PID00_RS01245 Protein ID WP_001110446.1
Coordinates 260267..260560 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID00_RS01220 (254969) 254969..256066 + 1098 WP_000589326.1 flagellar basal body P-ring protein FlgI -
PID00_RS01225 (256066) 256066..257007 + 942 WP_096121915.1 flagellar assembly peptidoglycan hydrolase FlgJ -
PID00_RS01230 (257073) 257073..258716 + 1644 WP_042105957.1 flagellar hook-associated protein FlgK -
PID00_RS01235 (258728) 258728..259681 + 954 WP_001212762.1 flagellar hook-associated protein FlgL -
PID00_RS01240 (259776) 259776..260270 - 495 WP_000613624.1 GNAT family N-acetyltransferase Toxin
PID00_RS01245 (260267) 260267..260560 - 294 WP_001110446.1 DUF1778 domain-containing protein Antitoxin
PID00_RS01250 (260694) 260694..263879 - 3186 WP_001563106.1 ribonuclease E -
PID00_RS01255 (264452) 264452..265411 + 960 WP_001563107.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18142.04 Da        Isoelectric Point: 7.7444

>T267747 WP_000613624.1 NZ_CP116067:c260270-259776 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIDRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11079.67 Da        Isoelectric Point: 10.5423

>AT267747 WP_001110446.1 NZ_CP116067:c260560-260267 [Escherichia coli]
MPAANNIPARRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829G775

References