Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 74867..76416 Replicon plasmid 2
Accession NC_017385
Organism Ketogulonicigenium vulgare WSH-001

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KVU_RS15345 Protein ID WP_014538165.1
Coordinates 75118..76416 (+) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KVU_RS15340 Protein ID WP_044008278.1
Coordinates 74867..75118 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KVU_RS15325 71156..72007 - 852 WP_014538163.1 ABC transporter permease -
KVU_RS15330 72017..72967 - 951 WP_013385705.1 ABC transporter permease -
KVU_RS15335 72986..74560 - 1575 WP_014538164.1 ABC transporter substrate-binding protein -
KVU_RS15340 74867..75118 + 252 WP_044008278.1 helix-turn-helix domain-containing protein Antitoxin
KVU_RS15345 75118..76416 + 1299 WP_014538165.1 type II toxin-antitoxin system HipA family toxin Toxin
KVU_RS15350 76560..78386 - 1827 WP_014538166.1 response regulator -
KVU_RS15355 78379..79254 - 876 WP_014538167.1 chemotaxis protein CheR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..242715 242715


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-54)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 46516.30 Da        Isoelectric Point: 7.7322

>T26774 WP_014538165.1 NC_017385:75118-76416 [Ketogulonicigenium vulgare WSH-001]
MGRRRAYPPLDVYMNARLVGQFARQSGGAHLFTYAQSWLDWPGRLPISRALPLQGARHQGAAVIAVFDNLLPDHPQIRDR
LAARVGAGGADAFSLLAEIGRDCVGALQFLPAGEVPDAQGLQADPLSAAQIGALLSNLSAAPLGLDRTRDFRISVAGAQE
KTALLRQGDQWFAPRGATPTTHILKPAIGLLPSGVDLRNAPQNEHFCLRLLAGFGLRVADTQVADFNGLSTLVVTRFDRL
WTADGRLIRLPQEDCCQALGVPSSLKYQSDGGPGIREISALLQASDQPVQDRLDFFKANILFWLMGATDGHAKNFSLSMA
PGGRFRLAPLYDVISLQPALAAGQMQPGDMRLAMRMGASRYYRIGDITGRHILESGLDAGLSRVQVLAICAEIAESAAAA
FEAASDTVQDQEMIAAIRAGFDQRLPRLMTMT

Download         Length: 1299 bp

>T26774 NC_017385:75118-76416 [Ketogulonicigenium vulgare WSH-001]
ATGGGACGTCGCCGGGCCTATCCGCCATTGGATGTCTATATGAACGCACGTCTTGTCGGGCAGTTTGCGCGGCAAAGCGG
GGGCGCGCATCTGTTCACCTATGCGCAAAGCTGGCTGGACTGGCCGGGCCGGCTGCCGATCTCGCGGGCGTTGCCATTGC
AGGGCGCACGCCATCAAGGCGCGGCGGTGATTGCGGTTTTTGACAACCTGCTGCCCGATCACCCGCAGATCCGCGACCGT
CTGGCGGCGCGGGTCGGGGCGGGCGGTGCGGATGCGTTCAGCCTGCTGGCCGAGATTGGGCGCGATTGCGTCGGCGCGCT
GCAATTTCTGCCAGCGGGCGAGGTGCCTGACGCGCAGGGGCTGCAGGCCGATCCGCTGAGCGCGGCGCAGATTGGCGCGC
TGCTATCGAACCTGAGCGCCGCGCCGCTGGGGCTGGACCGCACGCGGGACTTCCGCATTTCGGTCGCTGGGGCGCAGGAA
AAGACGGCGCTGCTGCGGCAGGGCGATCAGTGGTTCGCGCCGCGCGGGGCGACCCCTACGACCCATATCCTGAAACCCGC
GATCGGGCTGCTGCCCAGTGGGGTCGATCTGCGCAACGCCCCCCAGAACGAGCATTTCTGTCTGCGCCTGCTGGCCGGTT
TCGGTCTGCGCGTGGCTGACACGCAGGTTGCGGATTTCAATGGCCTCAGCACGCTGGTTGTCACCCGGTTTGACCGGCTG
TGGACGGCGGATGGGCGGTTGATCCGCCTGCCGCAAGAGGATTGCTGTCAGGCCCTCGGCGTGCCGTCCAGCCTGAAATA
TCAAAGCGATGGCGGCCCGGGCATCCGCGAGATCAGCGCGCTGTTGCAGGCCAGCGATCAGCCGGTGCAGGACCGGTTGG
ATTTTTTCAAGGCGAATATCCTGTTCTGGCTGATGGGCGCGACCGATGGCCATGCCAAGAATTTCAGCCTGTCCATGGCC
CCCGGCGGGCGGTTCCGGCTGGCACCGCTGTATGATGTGATCAGCCTGCAACCGGCGCTGGCGGCGGGGCAGATGCAGCC
CGGGGATATGCGCCTCGCGATGCGGATGGGGGCAAGCCGCTATTATCGCATAGGGGATATCACCGGCCGCCATATTCTGG
AAAGCGGGCTGGATGCCGGATTGTCGCGGGTGCAGGTCCTGGCGATTTGCGCTGAGATTGCCGAAAGCGCCGCCGCGGCC
TTTGAGGCGGCATCAGACACAGTGCAGGACCAGGAGATGATCGCGGCGATCCGCGCGGGGTTTGACCAGCGCTTGCCCAG
ACTGATGACAATGACCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9042.29 Da        Isoelectric Point: 5.6379

>AT26774 WP_044008278.1 NC_017385:74867-75118 [Ketogulonicigenium vulgare WSH-001]
MDHIIRSPKDIGHVLRQARKAGGLSQADLAAKAGLWQRTVSTLETGAADARLETLFDLLAALDLELQVVPRSRTDPDSFA
DLF

Download         Length: 252 bp

>AT26774 NC_017385:74867-75118 [Ketogulonicigenium vulgare WSH-001]
ATGGACCATATCATTCGCTCACCCAAAGATATCGGACATGTGCTGCGGCAGGCCCGCAAGGCAGGGGGGCTGTCGCAGGC
TGACCTTGCCGCAAAAGCGGGCCTGTGGCAGCGCACGGTTTCCACGCTGGAAACCGGCGCGGCGGATGCAAGGCTGGAAA
CGCTGTTTGATCTGCTCGCCGCGCTGGATCTGGAATTGCAGGTCGTGCCGCGCAGCCGCACCGATCCCGACAGTTTTGCC
GATCTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References