Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2187064..2187905 Replicon chromosome
Accession NZ_CP116046
Organism Escherichia coli strain EC812A1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag PIH14_RS10685 Protein ID WP_000854822.1
Coordinates 2187064..2187447 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0CWL2
Locus tag PIH14_RS10690 Protein ID WP_053271974.1
Coordinates 2187537..2187905 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIH14_RS10655 (2182709) 2182709..2184550 + 1842 WP_000437375.1 RNA polymerase sigma factor RpoD -
PIH14_RS10660 (2184629) 2184629..2185135 - 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
PIH14_RS10670 (2185434) 2185434..2186279 - 846 WP_001280435.1 DUF4942 domain-containing protein -
PIH14_RS10675 (2186376) 2186376..2186573 - 198 WP_000839263.1 DUF957 domain-containing protein -
PIH14_RS10680 (2186585) 2186585..2187073 - 489 WP_001177592.1 DUF5983 family protein -
PIH14_RS10685 (2187064) 2187064..2187447 - 384 WP_000854822.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
PIH14_RS10690 (2187537) 2187537..2187905 - 369 WP_053271974.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PIH14_RS10695 (2187985) 2187985..2188206 - 222 WP_000692312.1 DUF987 domain-containing protein -
PIH14_RS10700 (2188275) 2188275..2188751 - 477 WP_001186747.1 RadC family protein -
PIH14_RS10705 (2188766) 2188766..2189251 - 486 WP_112915495.1 antirestriction protein -
PIH14_RS10710 (2189342) 2189342..2190160 - 819 WP_001234702.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T267735 WP_000854822.1 NZ_CP116046:c2187447-2187064 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13679.41 Da        Isoelectric Point: 6.4758

>AT267735 WP_053271974.1 NZ_CP116046:c2187905-2187537 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0CWL2

References