Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1116287..1117118 Replicon chromosome
Accession NZ_CP116046
Organism Escherichia coli strain EC812A1

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag PIH14_RS05620 Protein ID WP_000854814.1
Coordinates 1116744..1117118 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag PIH14_RS05615 Protein ID WP_001285585.1
Coordinates 1116287..1116655 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIH14_RS05570 (1111489) 1111489..1111734 + 246 Protein_1093 transposase -
PIH14_RS05575 (1111747) 1111747..1112898 - 1152 WP_001254932.1 IS30-like element IS30 family transposase -
PIH14_RS05580 (1113445) 1113445..1113813 - 369 Protein_1095 zinc-ribbon domain-containing protein -
PIH14_RS05585 (1113801) 1113801..1114202 - 402 WP_000270974.1 putative zinc ribbon protein -
PIH14_RS05590 (1114462) 1114462..1114548 - 87 Protein_1097 inovirus-type Gp2 protein -
PIH14_RS05595 (1114548) 1114548..1114880 + 333 Protein_1098 DUF932 domain-containing protein -
PIH14_RS05600 (1114962) 1114962..1115441 + 480 WP_000860087.1 antirestriction protein -
PIH14_RS05605 (1115453) 1115453..1115929 + 477 WP_001186726.1 RadC family protein -
PIH14_RS05610 (1115992) 1115992..1116213 + 222 WP_000692323.1 DUF987 domain-containing protein -
PIH14_RS05615 (1116287) 1116287..1116655 + 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
PIH14_RS05620 (1116744) 1116744..1117118 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
PIH14_RS05625 (1117115) 1117115..1117309 + 195 WP_000988600.1 DUF5983 family protein -
PIH14_RS05630 (1117355) 1117355..1117435 + 81 Protein_1105 hypothetical protein -
PIH14_RS05635 (1117724) 1117724..1117852 - 129 Protein_1106 transposase domain-containing protein -
PIH14_RS05640 (1117972) 1117972..1118106 + 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
PIH14_RS05645 (1118207) 1118207..1118536 - 330 WP_000450409.1 DUF496 family protein -
PIH14_RS05650 (1118708) 1118708..1119766 - 1059 WP_271293169.1 FUSC family protein -
PIH14_RS05655 (1119964) 1119964..1120437 - 474 WP_271293170.1 DNA gyrase inhibitor SbmC -
PIH14_RS05660 (1120556) 1120556..1121722 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T267731 WP_000854814.1 NZ_CP116046:1116744-1117118 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp


Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT267731 WP_001285585.1 NZ_CP116046:1116287-1116655 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829FY50


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References