Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 632136..633685 Replicon chromosome
Accession NZ_CP116046
Organism Escherichia coli strain EC812A1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PIH14_RS03125 Protein ID WP_271293150.1
Coordinates 632136..633419 (-) Length 428 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PIH14_RS03130 Protein ID WP_001301023.1
Coordinates 633419..633685 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIH14_RS03110 (628770) 628770..630434 - 1665 WP_106421409.1 integrase -
PIH14_RS03115 (630397) 630397..630945 - 549 WP_227454831.1 hypothetical protein -
PIH14_RS03120 (630926) 630926..631858 - 933 WP_271293149.1 hypothetical protein -
PIH14_RS03125 (632136) 632136..633419 - 1284 WP_271293150.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
PIH14_RS03130 (633419) 633419..633685 - 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PIH14_RS03135 (633908) 633908..636049 - 2142 Protein_617 autotransporter outer membrane beta-barrel domain-containing protein -
PIH14_RS03140 (636509) 636509..638101 - 1593 WP_000113145.1 autoinducer-2 kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 428 a.a.        Molecular weight: 47726.10 Da        Isoelectric Point: 7.4784

>T267726 WP_271293150.1 NZ_CP116046:c633419-632136 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAMGFGHC

Download         Length: 1284 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT267726 WP_001301023.1 NZ_CP116046:c633685-633419 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References