Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 547800..548438 Replicon chromosome
Accession NZ_CP116046
Organism Escherichia coli strain EC812A1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PIH14_RS02745 Protein ID WP_000813794.1
Coordinates 547800..547976 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PIH14_RS02750 Protein ID WP_001270286.1
Coordinates 548022..548438 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIH14_RS02725 (543419) 543419..544594 - 1176 WP_001236265.1 BenE family transporter YdcO -
PIH14_RS02730 (544686) 544686..545222 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
PIH14_RS02735 (545295) 545295..547256 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PIH14_RS02740 (547348) 547348..547578 - 231 WP_000494244.1 YncJ family protein -
PIH14_RS02745 (547800) 547800..547976 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PIH14_RS02750 (548022) 548022..548438 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PIH14_RS02755 (548517) 548517..549923 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
PIH14_RS02760 (550168) 550168..551313 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
PIH14_RS02765 (551331) 551331..552344 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
PIH14_RS02770 (552345) 552345..553286 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T267725 WP_000813794.1 NZ_CP116046:547800-547976 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT267725 WP_001270286.1 NZ_CP116046:548022-548438 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References