Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 51658..52283 Replicon plasmid p_STEC1575_1
Accession NZ_CP116045
Organism Escherichia coli strain STEC1575

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PHA55_RS24430 Protein ID WP_000911315.1
Coordinates 51885..52283 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag PHA55_RS24425 Protein ID WP_000450532.1
Coordinates 51658..51885 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA55_RS24425 (51658) 51658..51885 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
PHA55_RS24430 (51885) 51885..52283 + 399 WP_000911315.1 type II toxin-antitoxin system VapC family toxin Toxin
PHA55_RS24435 (52292) 52292..54445 - 2154 WP_161619128.1 type IV conjugative transfer system coupling protein TraD -
PHA55_RS24440 (54698) 54698..55429 - 732 WP_000850422.1 conjugal transfer complement resistance protein TraT -
PHA55_RS24445 (55454) 55454..55975 - 522 WP_000632670.1 conjugal transfer entry exclusion protein TraS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - hlyD 1..88676 88676


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14871.17 Da        Isoelectric Point: 8.5264

>T267724 WP_000911315.1 NZ_CP116045:51885-52283 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQARPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT267724 WP_000450532.1 NZ_CP116045:51658-51885 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References