Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4683598..4684229 Replicon chromosome
Accession NZ_CP116044
Organism Escherichia coli strain STEC1575

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag PHA55_RS22910 Protein ID WP_001259388.1
Coordinates 4683954..4684229 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag PHA55_RS22905 Protein ID WP_000593555.1
Coordinates 4683598..4683957 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA55_RS22880 (4679730) 4679730..4680674 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
PHA55_RS22885 (4680671) 4680671..4681504 + 834 WP_042099188.1 nickel ABC transporter permease subunit NikC -
PHA55_RS22890 (4681504) 4681504..4682268 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
PHA55_RS22895 (4682265) 4682265..4683071 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
PHA55_RS22900 (4683077) 4683077..4683478 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
PHA55_RS22905 (4683598) 4683598..4683957 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PHA55_RS22910 (4683954) 4683954..4684229 - 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
PHA55_RS22915 (4684302) 4684302..4685426 - 1125 WP_001216257.1 ABC transporter permease -
PHA55_RS22920 (4685426) 4685426..4688161 - 2736 WP_000149124.1 ribosome-associated ATPase/putative transporter RbbA -
PHA55_RS22925 (4688158) 4688158..4689225 - 1068 WP_000361485.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T267721 WP_001259388.1 NZ_CP116044:c4684229-4683954 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT267721 WP_000593555.1 NZ_CP116044:c4683957-4683598 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References