Detailed information of TA system TA026772

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1484310..1485517
• Replicon: chromosome
• Accession: NC_017382
• Organism: Helicobacter pylori 51

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: KHP_RS07245
• Protein ID: WP_041202056.1
• Coordinates: 1484310..1485017 (-)
• Length: 236 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: KHP_RS07250
• Protein ID: WP_000248397.1
• Coordinates: 1485080..1485517 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KHP_RS07235	1481646..1482806	+	1161	WP_001051179.1	L-seryl-tRNA(Sec) selenium transferase	-
KHP_RS07240	1482894..1484081	+	1188	WP_000411584.1	transcription termination/antitermination protein NusA	-
KHP_RS07245	1484310..1485017	-	708	WP_041202056.1	hypothetical protein	Toxin
KHP_RS07250	1485080..1485517	-	438	WP_000248397.1	SocA family protein	Antitoxin
KHP_RS08275	1485741..1487369	-	1629	Protein_1381	RNA-directed DNA polymerase	-
KHP_RS07270	1487380..1487901	-	522	WP_000413030.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 236 a.a.
• Molecular weight: 27577.41 Da
• Isoelectric Point: 9.9353

>T26772 WP_041202056.1 NC_017382:c1485017-1484310 [Helicobacter pylori 51]
MSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQDNKEVESIKPKLEKLYDHMNLECI
RLQDFDEKMSRVKDVSIRLDNLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVGGLAFSTSVLSNIDKANAYRLVFVM
AFIALFFGNILYLLFSFLSKISLSSKISLSKEERDKQENFFKKPIFWFNLMVTILFVIGFFGELHIIQRLVSKYL

Nucleotide

• Length: 708 bp

>T26772 NC_017382:c1485017-1484310 [Helicobacter pylori 51]
TTGTCCAGCCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATAAAGGAGAATACAAGCATAAATATTCAAAAAT
CACAACTATTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACGCTCAAAG
AGATTCAAGATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATC
AGACTGCAAGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAGGTTAGATAATCTAAATAAAAACTATAA
AAAATTAAGCGAAGAATTGAATAAGCAACAAACACAATACATAACAATTCTAGGTATTTTTGCCTCTATTGTTTTAACAT
TTGTTGGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATG
GCTTTTATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCATCAAAAAT
ATCCTTATCAAAAGAGGAAAGAGATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTAATGGTTACAA
TTCTATTTGTGATTGGTTTTTTTGGAGAATTGCATATAATACAAAGATTAGTTTCTAAATATCTTTGA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17315.43 Da
• Isoelectric Point: 6.4976

>AT26772 WP_000248397.1 NC_017382:c1485517-1485080 [Helicobacter pylori 51]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVSREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINRSIKKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT26772 NC_017382:c1485517-1485080 [Helicobacter pylori 51]
ATGGTCAATACTTTGGAATTAGCAAAATATATTCTTAAGCATTCCAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTTCAAGAGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCTATTGACAAACCTAAAGAAGAAACGCTC
TCACAAAATCTTAGAGAAGATGAATTGGAAACCATCAATCGCTCCATAAAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAATTAA