Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3585232..3585857 Replicon chromosome
Accession NZ_CP116044
Organism Escherichia coli strain STEC1575

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag PHA55_RS17515 Protein ID WP_000911329.1
Coordinates 3585232..3585630 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PHA55_RS17520 Protein ID WP_000450524.1
Coordinates 3585630..3585857 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA55_RS17495 (3581110) 3581110..3581310 + 201 WP_000383836.1 YpfN family protein -
PHA55_RS17500 (3581420) 3581420..3582118 - 699 WP_000679823.1 esterase -
PHA55_RS17505 (3582192) 3582192..3584207 - 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
PHA55_RS17510 (3584222) 3584222..3585085 - 864 WP_001267498.1 neutral zinc metallopeptidase -
PHA55_RS17515 (3585232) 3585232..3585630 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
PHA55_RS17520 (3585630) 3585630..3585857 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PHA55_RS17525 (3586011) 3586011..3586724 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PHA55_RS17530 (3586937) 3586937..3587971 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PHA55_RS17535 (3587988) 3587988..3588866 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PHA55_RS17540 (3589012) 3589012..3589584 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PHA55_RS17545 (3589584) 3589584..3590054 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T267716 WP_000911329.1 NZ_CP116044:c3585630-3585232 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT267716 WP_000450524.1 NZ_CP116044:c3585857-3585630 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References