Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2416925..2417563 Replicon chromosome
Accession NZ_CP116044
Organism Escherichia coli strain STEC1575

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PHA55_RS11810 Protein ID WP_000813794.1
Coordinates 2416925..2417101 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PHA55_RS11815 Protein ID WP_001270286.1
Coordinates 2417147..2417563 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA55_RS11790 (2412544) 2412544..2413758 - 1215 WP_071601296.1 BenE family transporter YdcO -
PHA55_RS11795 (2413811) 2413811..2414347 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
PHA55_RS11800 (2414420) 2414420..2416381 + 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PHA55_RS11805 (2416473) 2416473..2416703 - 231 WP_000494244.1 YncJ family protein -
PHA55_RS11810 (2416925) 2416925..2417101 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PHA55_RS11815 (2417147) 2417147..2417563 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PHA55_RS11820 (2417642) 2417642..2419048 + 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
PHA55_RS11825 (2419293) 2419293..2420438 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
PHA55_RS11830 (2420456) 2420456..2421469 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
PHA55_RS11835 (2421470) 2421470..2422411 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2411356..2412504 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T267709 WP_000813794.1 NZ_CP116044:2416925-2417101 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT267709 WP_001270286.1 NZ_CP116044:2417147-2417563 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References