Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1363694..1364312 Replicon chromosome
Accession NZ_CP116044
Organism Escherichia coli strain STEC1575

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PHA55_RS06645 Protein ID WP_001291435.1
Coordinates 1363694..1363912 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PHA55_RS06650 Protein ID WP_000344800.1
Coordinates 1363938..1364312 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA55_RS06610 (1358983) 1358983..1359555 + 573 WP_000779826.1 YbaY family lipoprotein -
PHA55_RS06615 (1359586) 1359586..1359897 - 312 WP_000409911.1 MGMT family protein -
PHA55_RS06625 (1360276) 1360276..1360629 + 354 WP_271287507.1 DUF1428 family protein -
PHA55_RS06630 (1360671) 1360671..1362221 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PHA55_RS06635 (1362385) 1362385..1362855 - 471 WP_000136192.1 YlaC family protein -
PHA55_RS06640 (1362971) 1362971..1363522 - 552 WP_000102568.1 maltose O-acetyltransferase -
PHA55_RS06645 (1363694) 1363694..1363912 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PHA55_RS06650 (1363938) 1363938..1364312 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PHA55_RS06655 (1364858) 1364858..1368007 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PHA55_RS06660 (1368030) 1368030..1369223 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T267700 WP_001291435.1 NZ_CP116044:c1363912-1363694 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT267700 WP_000344800.1 NZ_CP116044:c1364312-1363938 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References