267699

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1329397..1330234 Replicon chromosome
Accession NZ_CP116044
Organism Escherichia coli strain STEC1575

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag PHA55_RS06475 Protein ID WP_000227784.1
Coordinates 1329397..1329939 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag PHA55_RS06480 Protein ID WP_001297137.1
Coordinates 1329923..1330234 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA55_RS06455 (1324936) 1324936..1325847 - 912 WP_000705849.1 2-dehydropantoate 2-reductase -
PHA55_RS06460 (1326015) 1326015..1326506 + 492 WP_001138904.1 nucleotide binding protein YajQ -
PHA55_RS06465 (1326634) 1326634..1327998 - 1365 WP_001000978.1 MFS transporter -
PHA55_RS06470 (1328406) 1328406..1329341 + 936 WP_001297127.1 tetratricopeptide repeat protein -
PHA55_RS06475 (1329397) 1329397..1329939 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
PHA55_RS06480 (1329923) 1329923..1330234 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
PHA55_RS06485 (1330419) 1330419..1331309 - 891 WP_000971336.1 heme o synthase -
PHA55_RS06490 (1331321) 1331321..1331650 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
PHA55_RS06495 (1331650) 1331650..1332264 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
PHA55_RS06500 (1332254) 1332254..1334245 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
PHA55_RS06505 (1334267) 1334267..1335214 - 948 WP_001239440.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T267699 WP_000227784.1 NZ_CP116044:c1329939-1329397 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT267699 WP_001297137.1 NZ_CP116044:c1330234-1329923 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References