Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4440475..4441256 Replicon chromosome
Accession NZ_CP116042
Organism Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain BL708

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag PGC28_RS21840 Protein ID WP_000626099.1
Coordinates 4440475..4440966 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag PGC28_RS21845 Protein ID WP_001110452.1
Coordinates 4440963..4441256 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGC28_RS21800 (4435661) 4435661..4435903 - 243 WP_197603740.1 hypothetical protein -
PGC28_RS21805 (4435900) 4435900..4436256 - 357 WP_033567083.1 hypothetical protein -
PGC28_RS21810 (4436253) 4436253..4437125 - 873 WP_033567082.1 ParA family protein -
PGC28_RS21815 (4437316) 4437316..4437393 - 78 Protein_4267 helix-turn-helix domain-containing protein -
PGC28_RS21820 (4437484) 4437484..4437816 - 333 WP_001165471.1 MerR family transcriptional regulator -
PGC28_RS21825 (4437888) 4437888..4438265 + 378 WP_000916345.1 EthD family reductase -
PGC28_RS21830 (4439298) 4439298..4439372 + 75 Protein_4270 porin family protein -
PGC28_RS21835 (4439475) 4439475..4440227 + 753 WP_000842434.1 non-specific acid phosphatase -
PGC28_RS21840 (4440475) 4440475..4440966 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
PGC28_RS21845 (4440963) 4440963..4441256 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
PGC28_RS21850 (4441573) 4441573..4441794 + 222 WP_001576552.1 hypothetical protein -
PGC28_RS21855 (4442059) 4442059..4442934 + 876 WP_000921674.1 AraC family transcriptional regulator -
PGC28_RS21860 (4442931) 4442931..4443218 + 288 WP_001269916.1 transcriptional regulator RtsB -
PGC28_RS21865 (4443241) 4443241..4443456 + 216 WP_001595136.1 hypothetical protein -
PGC28_RS21870 (4443464) 4443464..4443733 + 270 WP_010989096.1 hypothetical protein -
PGC28_RS21875 (4444027) 4444027..4444932 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T267692 WP_000626099.1 NZ_CP116042:c4440966-4440475 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT267692 WP_001110452.1 NZ_CP116042:c4441256-4440963 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References