Detailed information of TA system TA026768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1495805..1496960
• Replicon: chromosome
• Accession: NC_017378
• Organism: Helicobacter pylori Puno120

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: HPPN120_RS07170
• Protein ID: WP_014537008.1
• Coordinates: 1495805..1496533 (-)
• Length: 243 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: G2M6T6
• Locus tag: HPPN120_RS07175
• Protein ID: WP_000248384.1
• Coordinates: 1496523..1496960 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPPN120_RS07160	1493117..1494277	+	1161	WP_001051175.1	L-seryl-tRNA(Sec) selenium transferase	-
HPPN120_RS07165	1494359..1495546	+	1188	WP_000411651.1	transcription termination/antitermination protein NusA	-
HPPN120_RS07170	1495805..1496533	-	729	WP_014537008.1	hypothetical protein	Toxin
HPPN120_RS07175	1496523..1496960	-	438	WP_000248384.1	SocA family protein	Antitoxin
HPPN120_RS07180	1497185..1498810	-	1626	WP_041200357.1	RNA-directed DNA polymerase	-
HPPN120_RS07185	1498821..1499345	-	525	WP_000413003.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 243 a.a.
• Molecular weight: 28306.14 Da
• Isoelectric Point: 6.5010

>T26768 WP_014537008.1 NC_017378:c1496533-1495805 [Helicobacter pylori Puno120]
METKEEDKDKKLEEIIVLLCKEGDLSGQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMTLTQNIKTLKEIQ
DIKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEEKDKQENFKKPIFWFNLMVTILFMIGFLEN
CI

Nucleotide

• Length: 729 bp

>T26768 NC_017378:c1496533-1495805 [Helicobacter pylori Puno120]
ATGGAAACTAAAGAAGAAGATAAAGATAAAAAGCTAGAAGAAATTATTGTATTGCTGTGCAAAGAGGGGGATTTGTCTGG
TCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGACGCTCACACAAAATATAAAGACACTCAAAGAGATTCAG
GATATTAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAGATGATCTAAATAAAAACTATAAAAAATTAA
GCGAAGAATTGAATAAGCAACAAACACAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTTGGG
GGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTTTAT
AGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGGAAAAAGATA
AACAAGAAAATTTCAAAAAACCTATTTTTTGGTTTAATCTAATGGTTACGATTCTATTTATGATTGGTTTTTTGGAGAAC
TGCATATAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17325.47 Da
• Isoelectric Point: 6.2653

>AT26768 WP_000248384.1 NC_017378:c1496960-1496523 [Helicobacter pylori Puno120]
MVNTLELAKYILKHSDKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSINKPKEETL
SQNLREDELETINRSIKKCNEKSYWDLVKESHKEDGAWYKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT26768 NC_017378:c1496960-1496523 [Helicobacter pylori Puno120]
ATGGTCAATACTTTGGAACTAGCAAAATATATTCTTAAGCATTCAGACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGAGAAGTGTATTATGAATATCGCAATTACGGTGCCAATTCTATTAACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAGAAGATGAACTTGAAACCATCAATCGCTCCATAAAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGTATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAACTAA

Structures

Antitoxin

• AlphaFold DB: G2M6T6