Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 33511..34643 Replicon chromosome
Accession NZ_CP116040
Organism Acinetobacter haemolyticus strain HW-2

Toxin (Protein)


Gene name - Uniprot ID A0A2K8PX24
Locus tag PGW89_RS00160 Protein ID WP_017396077.1
Coordinates 33511..34275 (-) Length 255 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID N9FA41
Locus tag PGW89_RS00165 Protein ID WP_004639219.1
Coordinates 34272..34643 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGW89_RS00135 (PGW89_00135) 29419..30276 + 858 WP_004639225.1 3-deoxy-8-phosphooctulonate synthase -
PGW89_RS00140 (PGW89_00140) 30368..31657 + 1290 WP_004639224.1 phosphopyruvate hydratase -
PGW89_RS00145 (PGW89_00145) 31787..32152 + 366 WP_004639223.1 cell division protein FtsB -
PGW89_RS00150 (PGW89_00150) 32142..32849 + 708 WP_113997251.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
PGW89_RS00155 (PGW89_00155) 32976..33452 + 477 WP_113997252.1 DUF6438 domain-containing protein -
PGW89_RS00160 (PGW89_00160) 33511..34275 - 765 WP_017396077.1 RES family NAD+ phosphorylase Toxin
PGW89_RS00165 (PGW89_00165) 34272..34643 - 372 WP_004639219.1 DUF2384 domain-containing protein Antitoxin
PGW89_RS00170 (PGW89_00170) 34859..35272 + 414 WP_005080585.1 YeeE/YedE thiosulfate transporter family protein -
PGW89_RS00175 (PGW89_00175) 35274..35687 + 414 WP_005090445.1 YeeE/YedE thiosulfate transporter family protein -
PGW89_RS00180 (PGW89_00180) 35702..36574 + 873 WP_017396076.1 MBL fold metallo-hydrolase -
PGW89_RS00185 (PGW89_00185) 36743..37441 + 699 WP_005080590.1 histidine phosphatase family protein -
PGW89_RS00190 (PGW89_00190) 37583..37843 + 261 WP_005080592.1 hypothetical protein -
PGW89_RS00195 (PGW89_00195) 37970..38554 + 585 WP_113997253.1 uracil-DNA glycosylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(68-206)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(73-121)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29082.00 Da        Isoelectric Point: 5.8003

>T267673 WP_017396077.1 NZ_CP116040:c34275-33511 [Acinetobacter haemolyticus]
MTAIEQNLWQSCEGNKQVSPLSGTLYRLVESQEQIATRQLVDTLEEQALLEDMLELVKPPYPPKSEHLHYLLKTPFRYPP
LKWGSRFGRTFEPSIFYGGCSVNVTLAESAYYRFVFWHSMDGAPKKKTIRTEHTLFSVGYHCHKGIRLQSPPFDQYLDLI
AHPTNYSYAQLLGTAMRNEGIEIFEYPSARASDHATCVGLFTAEHFSQNSPLDREQWFCDIGAEEVIFKAVEGSDIVRFE
LSQFLQQGIFPMPA

Download         Length: 765 bp

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13291.58 Da        Isoelectric Point: 10.4005

>AT267673 WP_004639219.1 NZ_CP116040:c34643-34272 [Acinetobacter haemolyticus]
MSALLKQPADKKVVLAKAVLSAAEQLDLKQVQLAAILGVHRTAISRLKNNPELDPASKQGELALLLIRLSRALYALTGGD
TDWMRHFLNTPNRVTGGIPVEQIESISGLVSVLQFVDAIRGKV

Download         Length: 372 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8PX24

Antitoxin

Source ID Structure
AlphaFold DB N9FA41

References