Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 889817..890450 Replicon chromosome
Accession NC_017378
Organism Helicobacter pylori Puno120

Toxin (Protein)


Gene name relE Uniprot ID G2M4Y4
Locus tag HPPN120_RS04240 Protein ID WP_000916160.1
Coordinates 889817..890092 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G2M4Y5
Locus tag HPPN120_RS04245 Protein ID WP_001133850.1
Coordinates 890073..890450 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPPN120_RS04215 885282..886415 - 1134 WP_000797814.1 glycosyltransferase family 8 protein -
HPPN120_RS04220 886478..887245 - 768 WP_000242345.1 ABC transporter ATP-binding protein -
HPPN120_RS04225 887245..888225 - 981 WP_000921442.1 iron ABC transporter permease -
HPPN120_RS04230 888218..889066 - 849 WP_000504121.1 SDR family oxidoreductase -
HPPN120_RS04235 889207..889731 + 525 WP_001120215.1 acyl-CoA thioesterase -
HPPN120_RS04240 889817..890092 - 276 WP_000916160.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPPN120_RS04245 890073..890450 - 378 WP_001133850.1 hypothetical protein Antitoxin
HPPN120_RS04250 890702..892942 - 2241 WP_000716256.1 outer membrane beta-barrel protein -
HPPN120_RS04265 893287..893913 + 627 WP_001146881.1 hypothetical protein -
HPPN120_RS04270 893864..894976 - 1113 WP_000115667.1 hydrogenase formation protein HypD -
HPPN120_RS04275 894989..895225 - 237 WP_000335450.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10683.53 Da        Isoelectric Point: 9.0082

>T26767 WP_000916160.1 NC_017378:c890092-889817 [Helicobacter pylori Puno120]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVKDDELILLRLG
SHSELNHPHNL

Download         Length: 276 bp

>T26767 NC_017378:c890092-889817 [Helicobacter pylori Puno120]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAGGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAAGAAAAAAAGAACCGCTAGATCCACAATTTAAAGATCATGCTTTAAAGGGAAAGTGGAAGCCTT
TTAGGGAATGCCACATCAAAGCTGATATTTTGCTGGTGTATCTAGTGAAAGATGATGAGCTCATTTTGTTAAGGTTAGGC
AGTCATAGCGAGCTAAATCACCCGCACAACTTATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14589.52 Da        Isoelectric Point: 6.9339

>AT26767 WP_001133850.1 NC_017378:c890450-890073 [Helicobacter pylori Puno120]
MPNSPTKKDCTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNEVLQKISQAFDDKRDCCL
GHEIPNLETQQAMRDALNKETDLIVEDFSSYSDERKKALGVKTQS

Download         Length: 378 bp

>AT26767 NC_017378:c890450-890073 [Helicobacter pylori Puno120]
ATGCCTAACTCTCCCACCAAAAAAGACTGCACGCAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAAGTCTTGCAAAAAATCAGCCAAGCTTTTGACGATAAAAGAGATTGTTGTTTG
GGGCATGAAATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCACTCAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAGAGAAAAAAGGCGTTAGGTGTTAAAACTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G2M4Y4

Antitoxin

Source ID Structure
AlphaFold DB G2M4Y5

References