267663

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4506660..4507157 Replicon chromosome
Accession NZ_CP116035
Organism Escherichia coli strain FAH

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PGH49_RS22350 Protein ID WP_001173343.1
Coordinates 4506660..4506833 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag PGH49_RS22355 Protein ID WP_001312331.1
Coordinates 4506861..4507157 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGH49_RS22340 (4503330) 4503330..4504787 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
PGH49_RS22345 (4505024) 4505024..4506541 + 1518 WP_000003806.1 lysine--tRNA ligase -
PGH49_RS22350 (4506660) 4506660..4506833 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PGH49_RS22355 (4506861) 4506861..4507157 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PGH49_RS22360 (4507386) 4507386..4507658 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
PGH49_RS22365 (4507670) 4507670..4507900 - 231 WP_000373293.1 4Fe-4S mono-cluster protein YjdI -
PGH49_RS22370 (4508081) 4508081..4509712 + 1632 WP_001216482.1 sensor histidine kinase -
PGH49_RS22375 (4509709) 4509709..4510428 + 720 WP_001540474.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4450968..4507157 56189


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T267663 WP_001173343.1 NZ_CP116035:c4506833-4506660 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT267663 WP_001312331.1 NZ_CP116035:c4507157-4506861 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References