267661

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4236062..4236876 Replicon chromosome
Accession NZ_CP116035
Organism Escherichia coli strain FAH

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag PGH49_RS20965 Protein ID WP_001054376.1
Coordinates 4236062..4236319 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag PGH49_RS20970 Protein ID WP_001540600.1
Coordinates 4236331..4236876 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGH49_RS20940 (4231350) 4231350..4232456 + 1107 WP_001774143.1 N-acetylneuraminate epimerase -
PGH49_RS20945 (4232521) 4232521..4233501 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
PGH49_RS20950 (4233611) 4233611..4233816 + 206 Protein_4100 HNH endonuclease -
PGH49_RS20955 (4234084) 4234084..4235324 - 1241 Protein_4101 helicase YjhR -
PGH49_RS20960 (4235440) 4235440..4235571 + 132 WP_001309182.1 hypothetical protein -
PGH49_RS20965 (4236062) 4236062..4236319 + 258 WP_001054376.1 YjhX family toxin Toxin
PGH49_RS20970 (4236331) 4236331..4236876 + 546 WP_001540600.1 N-acetyltransferase Antitoxin
PGH49_RS20975 (4236932) 4236932..4237678 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
PGH49_RS20980 (4237847) 4237847..4238065 + 219 Protein_4106 hypothetical protein -
PGH49_RS20985 (4238103) 4238103..4238219 + 117 Protein_4107 VOC family protein -
PGH49_RS20990 (4238464) 4238464..4239585 + 1122 WP_000010829.1 M42 family metallopeptidase -
PGH49_RS20995 (4239582) 4239582..4239860 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
PGH49_RS21000 (4239872) 4239872..4241185 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4225848..4245100 19252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T267661 WP_001054376.1 NZ_CP116035:4236062-4236319 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT267661 WP_001540600.1 NZ_CP116035:4236331-4236876 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References