267655

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4082353..4082903 Replicon chromosome
Accession NZ_CP116035
Organism Escherichia coli strain FAH

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag PGH49_RS20210 Protein ID WP_001160966.1
Coordinates 4082353..4082667 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1NMQ0
Locus tag PGH49_RS20215 Protein ID WP_000125568.1
Coordinates 4082670..4082903 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGH49_RS20185 (4078028) 4078028..4079314 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
PGH49_RS20190 (4079314) 4079314..4080303 + 990 WP_000241225.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
PGH49_RS20195 (4080300) 4080300..4081121 + 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
PGH49_RS20200 (4081124) 4081124..4081501 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
PGH49_RS20205 (4081508) 4081508..4082356 + 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
PGH49_RS20210 (4082353) 4082353..4082667 - 315 WP_001160966.1 CcdB family protein Toxin
PGH49_RS20215 (4082670) 4082670..4082903 - 234 WP_000125568.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PGH49_RS20220 (4082989) 4082989..4083468 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
PGH49_RS20225 (4083660) 4083660..4085522 - 1863 WP_000377109.1 glutathione-regulated potassium-efflux system protein KefC -
PGH49_RS20230 (4085515) 4085515..4086045 - 531 WP_000600732.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
PGH49_RS20235 (4086153) 4086153..4087484 - 1332 WP_271293209.1 MFS transporter -
PGH49_RS20240 (4087543) 4087543..4087830 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T267655 WP_001160966.1 NZ_CP116035:c4082667-4082353 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8560.55 Da        Isoelectric Point: 5.8062

>AT267655 WP_000125568.1 NZ_CP116035:c4082903-4082670 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENTEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A829GEF2

References