Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 936822..937479 Replicon chromosome
Accession NC_017375
Organism Helicobacter pylori 83

Toxin (Protein)


Gene name VapD Uniprot ID T5D7N9
Locus tag HMPREF0462_RS04550 Protein ID WP_000271050.1
Coordinates 936822..937106 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F4D6C4
Locus tag HMPREF0462_RS04555 Protein ID WP_001133876.1
Coordinates 937087..937479 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF0462_RS04520 (932751) 932751..933518 - 768 WP_000242365.1 ABC transporter ATP-binding protein -
HMPREF0462_RS04525 (933518) 933518..934497 - 980 Protein_880 iron ABC transporter permease -
HMPREF0462_RS04530 (934490) 934490..935332 - 843 WP_000504105.1 SDR family oxidoreductase -
HMPREF0462_RS04535 (935472) 935472..935996 + 525 WP_001135616.1 acyl-CoA thioesterase -
HMPREF0462_RS04540 (936084) 936084..936355 - 272 Protein_883 type II toxin-antitoxin system mRNA interferase toxin, HP0892 family -
HMPREF0462_RS04545 (936342) 936342..936653 - 312 WP_001134078.1 type II toxin-antitoxin system antitoxin -
HMPREF0462_RS04550 (936822) 936822..937106 - 285 WP_000271050.1 endoribonuclease VapD Toxin
HMPREF0462_RS04555 (937087) 937087..937479 - 393 WP_001133876.1 hypothetical protein Antitoxin
HMPREF0462_RS04560 (938222) 938222..940447 - 2226 WP_000716221.1 outer membrane beta-barrel protein -
HMPREF0462_RS04575 (940876) 940876..941448 + 573 WP_229108918.1 helicase DnaB modulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11188.74 Da        Isoelectric Point: 4.8896

>T26765 WP_000271050.1 NC_017375:c937106-936822 [Helicobacter pylori 83]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

>T26765 NC_017375:c937106-936822 [Helicobacter pylori 83]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15118.22 Da        Isoelectric Point: 9.1472

>AT26765 WP_001133876.1 NC_017375:c937479-937087 [Helicobacter pylori 83]
MPNSPTKKDYTRYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNGLLQKISQAFDNKRDCCL
GRKIPNLETQQAMRDALNGVNLTQIDSLDDLTNELKRENGKGFENVCFSV

Download         Length: 393 bp

>AT26765 NC_017375:c937479-937087 [Helicobacter pylori 83]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGATGCATTAAATGGACTCTTGCAAAAAATCAGCCAAGCTTTTGATAATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGGGTTAATCTCACTCAAATTGATAG
TTTAGATGATCTTACAAACGAGTTAAAAAGAGAAAATGGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3UI3

Antitoxin

Source ID Structure
AlphaFold DB F4D6C4

References