Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 970597..971204 Replicon chromosome
Accession NZ_CP116026
Organism Enterococcus casseliflavus strain CQFYY22-063

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PEZ80_RS04600 Protein ID WP_115232059.1
Coordinates 970854..971204 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PEZ80_RS04595 Protein ID WP_074932272.1
Coordinates 970597..970860 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PEZ80_RS04575 (PEZ80_04575) 966322..967614 + 1293 WP_271292477.1 guanosine 5'-monophosphate oxidoreductase -
PEZ80_RS04580 (PEZ80_04580) 967739..968476 + 738 WP_005225435.1 tRNA pseudouridine(38-40) synthase TruA -
PEZ80_RS04585 (PEZ80_04585) 968519..969277 + 759 WP_271292478.1 type I methionyl aminopeptidase -
PEZ80_RS04590 (PEZ80_04590) 969881..969979 + 99 WP_115233064.1 type I toxin-antitoxin system Fst family toxin -
PEZ80_RS04595 (PEZ80_04595) 970597..970860 + 264 WP_074932272.1 PbsX family transcriptional regulator Antitoxin
PEZ80_RS04600 (PEZ80_04600) 970854..971204 + 351 WP_115232059.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PEZ80_RS04605 (PEZ80_04605) 971560..971985 - 426 WP_271292479.1 AsnC family transcriptional regulator -
PEZ80_RS04610 (PEZ80_04610) 972088..972633 + 546 WP_035006689.1 cysteine hydrolase family protein -
PEZ80_RS04615 (PEZ80_04615) 972961..973884 + 924 WP_271292480.1 peptide-methionine (S)-S-oxide reductase MsrA -
PEZ80_RS04620 (PEZ80_04620) 974234..975595 + 1362 WP_271292481.1 citrate transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin

Antitoxin PemI-like

(4-87)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13022.03 Da        Isoelectric Point: 8.0511

>T267638 WP_115232059.1 NZ_CP116026:970854-971204 [Enterococcus casseliflavus]
MVRKPRQGDILLLDTAPRAGHEQTGKRPYIVLSHDMIADYSNVATVAPISSTSRNYPLYVSINPDYGMKTTGKVLLDQLT
TIDYEASACVFLEKAHEHLVDELLMKVRTVFQKVSK

Download         Length: 351 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10186.61 Da        Isoelectric Point: 4.9099

>AT267638 WP_074932272.1 NZ_CP116026:970597-970860 [Enterococcus casseliflavus]
MEMLPIKKWGNSNGLRLPKYIMEYLGIHTDDKVKIIQEEVNGHKRLIIEAANLENELTIEELFENYTAERNHVEIQHLGE
AVGNEKW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References