Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 499552..500123 Replicon chromosome
Accession NZ_CP116023
Organism Enterococcus faecium strain CQFYH22-006

Toxin (Protein)


Gene name mazF Uniprot ID A0A828ZXV4
Locus tag PEZ79_RS02395 Protein ID WP_002302307.1
Coordinates 499782..500123 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag PEZ79_RS02390 Protein ID WP_002323011.1
Coordinates 499552..499782 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PEZ79_RS02365 (PEZ79_02365) 495003..496361 + 1359 WP_033631190.1 FAD-containing oxidoreductase -
PEZ79_RS02370 (PEZ79_02370) 496383..497009 + 627 WP_002323734.1 cysteine hydrolase -
PEZ79_RS02375 (PEZ79_02375) 497202..497783 + 582 WP_002300332.1 TetR/AcrR family transcriptional regulator -
PEZ79_RS02380 (PEZ79_02380) 498146..498721 + 576 WP_002302305.1 SOS response-associated peptidase family protein -
PEZ79_RS02385 (PEZ79_02385) 498926..499264 - 339 WP_002286804.1 hypothetical protein -
PEZ79_RS02390 (PEZ79_02390) 499552..499782 + 231 WP_002323011.1 hypothetical protein Antitoxin
PEZ79_RS02395 (PEZ79_02395) 499782..500123 + 342 WP_002302307.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PEZ79_RS02405 (PEZ79_02405) 502589..505093 + 2505 WP_002317782.1 prealbumin-like fold domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13288.65 Da        Isoelectric Point: 9.9044

>T267635 WP_002302307.1 NZ_CP116023:499782-500123 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIISQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT267635 WP_002323011.1 NZ_CP116023:499552-499782 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXV4

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References