Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 193850..194379 Replicon chromosome
Accession NZ_CP116023
Organism Enterococcus faecium strain CQFYH22-006

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag PEZ79_RS00960 Protein ID WP_002294198.1
Coordinates 194113..194379 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1S8JTG2
Locus tag PEZ79_RS00955 Protein ID WP_002317080.1
Coordinates 193850..194113 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PEZ79_RS00945 (PEZ79_00945) 191225..193048 + 1824 WP_002294202.1 APC family permease -
PEZ79_RS00950 (PEZ79_00950) 193190..193375 - 186 WP_002294201.1 hypothetical protein -
PEZ79_RS00955 (PEZ79_00955) 193850..194113 + 264 WP_002317080.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PEZ79_RS00960 (PEZ79_00960) 194113..194379 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
PEZ79_RS00965 (PEZ79_00965) 194580..195068 + 489 WP_002301120.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
PEZ79_RS00970 (PEZ79_00970) 195610..196281 - 672 WP_002319469.1 ABC transporter permease -
PEZ79_RS00975 (PEZ79_00975) 196278..197195 - 918 WP_002301114.1 osmoprotectant ABC transporter substrate-binding protein -
PEZ79_RS00980 (PEZ79_00980) 197192..197833 - 642 WP_002293405.1 ABC transporter permease -
PEZ79_RS00985 (PEZ79_00985) 197837..199012 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T267634 WP_002294198.1 NZ_CP116023:194113-194379 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10015.04 Da        Isoelectric Point: 4.1844

>AT267634 WP_002317080.1 NZ_CP116023:193850-194113 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
NIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8JTG2

References