267633

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1297426..1298343 Replicon chromosome
Accession NZ_CP116014
Organism Bacillus velezensis strain SRCM124633

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag PF996_RS06800 Protein ID WP_271265756.1
Coordinates 1297597..1298343 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag PF996_RS06795 Protein ID WP_003154807.1
Coordinates 1297426..1297596 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF996_RS06745 (1292632) 1292632..1293144 + 513 WP_017417605.1 sigma-70 family RNA polymerase sigma factor -
PF996_RS06750 (1293257) 1293257..1293808 + 552 Protein_1269 terminase -
PF996_RS06755 (1293919) 1293919..1294281 + 363 WP_014721043.1 hypothetical protein -
PF996_RS06760 (1294294) 1294294..1294665 + 372 WP_017417608.1 XkdW family protein -
PF996_RS06765 (1294670) 1294670..1294867 + 198 WP_007610833.1 XkdX family protein -
PF996_RS06770 (1294924) 1294924..1295685 + 762 WP_025649639.1 hypothetical protein -
PF996_RS06775 (1295737) 1295737..1296000 + 264 WP_100261725.1 hemolysin XhlA family protein -
PF996_RS06780 (1296014) 1296014..1296277 + 264 WP_003154813.1 phage holin -
PF996_RS06785 (1296291) 1296291..1297169 + 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
PF996_RS06790 (1297204) 1297204..1297329 - 126 WP_003154809.1 hypothetical protein -
PF996_RS06795 (1297426) 1297426..1297596 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
PF996_RS06800 (1297597) 1297597..1298343 - 747 WP_271265756.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PF996_RS06805 (1298447) 1298447..1299445 - 999 WP_017417610.1 inorganic phosphate transporter -
PF996_RS06810 (1299458) 1299458..1300075 - 618 WP_003154804.1 DUF47 domain-containing protein -
PF996_RS06815 (1300362) 1300362..1301678 - 1317 WP_007610842.1 amino acid permease -
PF996_RS06820 (1302000) 1302000..1302950 + 951 WP_007610844.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29063.54 Da        Isoelectric Point: 4.7755

>T267633 WP_271265756.1 NZ_CP116014:c1298343-1297597 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSGQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT267633 WP_003154807.1 NZ_CP116014:c1297596-1297426 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References