Detailed information of TA system TA026763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 923726..924350
• Replicon: chromosome
• Accession: NC_017372
• Organism: Helicobacter pylori India7 (Helicobacter pylori Ind7)

Toxin (Protein)

• Gene name: relE
• Uniprot ID: E8QGL5
• Locus tag: HPIN_RS04350
• Protein ID: WP_000912774.1
• Coordinates: 923726..923992 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E8QGL6
• Locus tag: HPIN_RS04355
• Protein ID: WP_001134058.1
• Coordinates: 923979..924350 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPIN_RS04320	919712..920479	-	768	WP_000242337.1	ABC transporter ATP-binding protein	-
HPIN_RS04325	920479..921459	-	981	WP_000921454.1	iron ABC transporter permease	-
HPIN_RS04330	921452..922306	-	855	WP_000538098.1	SDR family oxidoreductase	-
HPIN_RS04335	922447..922971	+	525	WP_001135602.1	acyl-CoA thioesterase	-
HPIN_RS04340	923079..923350	-	272	Protein_840	type II toxin-antitoxin system YafQ family toxin	-
HPIN_RS04345	923337..923648	-	312	WP_001134046.1	hypothetical protein	-
HPIN_RS04350	923726..923992	-	267	WP_000912774.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPIN_RS04355	923979..924350	-	372	WP_001134058.1	hypothetical protein	Antitoxin
HPIN_RS04360	924839..927085	-	2247	WP_014536153.1	Hop family adhesin BabA	-
HPIN_RS04375	927645..928274	+	630	WP_001146902.1	hypothetical protein	-
HPIN_RS04380	928225..929337	-	1113	WP_000109828.1	hydrogenase formation protein HypD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10420.43 Da
• Isoelectric Point: 10.0434

>T26763 WP_000912774.1 NC_017372:c923992-923726 [Helicobacter pylori India7]
MLKIKHHILYKKDFKKLVKNGFDDSVLNEVILTLRKKEPLPPQFQDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHSDLF

Nucleotide

• Length: 267 bp

>T26763 NC_017372:c923992-923726 [Helicobacter pylori India7]
ATGCTGAAAATTAAGCACCATATCCTTTACAAAAAAGATTTTAAAAAACTTGTTAAAAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGAAAGAACCATTACCCCCACAATTTCAAGATCATGCCTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCCGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTGATTTTGTTAAGA
CTAGGCAGTCATAGCGATCTGTTTTAA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 14507.31 Da
• Isoelectric Point: 5.0576

>AT26763 WP_001134058.1 NC_017372:c924350-923979 [Helicobacter pylori India7]
MPNTTAEKDYTQYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GHEIPNIQTQQAMRDALNGENLETIEDFSAWANEIKKEVNAEN

Nucleotide

• Length: 372 bp

>AT26763 NC_017372:c924350-923979 [Helicobacter pylori India7]
ATGCCAAACACCACCGCAGAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAATCTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTG
GGGCATGAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGACGCGTTAAATGGCGAAAACTTAGAAACTATTGAAGA
CTTTTCTGCATGGGCAAATGAAATAAAAAAGGAAGTGAATGCTGAAAATTAA

Structures

Toxin

• AlphaFold DB: E8QGL5

Antitoxin

• AlphaFold DB: E8QGL6