Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 923337..923992 Replicon chromosome
Accession NC_017372
Organism Helicobacter pylori India7 (Helicobacter pylori Ind7)

Toxin (Protein)


Gene name relE Uniprot ID E8QGL5
Locus tag HPIN_RS04350 Protein ID WP_000912774.1
Coordinates 923726..923992 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E8QGL4
Locus tag HPIN_RS04345 Protein ID WP_001134046.1
Coordinates 923337..923648 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPIN_RS04315 918533..919607 - 1075 Protein_835 glycosyltransferase family 8 protein -
HPIN_RS04320 919712..920479 - 768 WP_000242337.1 ABC transporter ATP-binding protein -
HPIN_RS04325 920479..921459 - 981 WP_000921454.1 iron ABC transporter permease -
HPIN_RS04330 921452..922306 - 855 WP_000538098.1 SDR family oxidoreductase -
HPIN_RS04335 922447..922971 + 525 WP_001135602.1 acyl-CoA thioesterase -
HPIN_RS04340 923079..923350 - 272 Protein_840 type II toxin-antitoxin system YafQ family toxin -
HPIN_RS04345 923337..923648 - 312 WP_001134046.1 hypothetical protein Antitoxin
HPIN_RS04350 923726..923992 - 267 WP_000912774.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPIN_RS04355 923979..924350 - 372 WP_001134058.1 hypothetical protein -
HPIN_RS04360 924839..927085 - 2247 WP_014536153.1 Hop family adhesin BabA -
HPIN_RS04375 927645..928274 + 630 WP_001146902.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10420.43 Da        Isoelectric Point: 10.0434

>T26762 WP_000912774.1 NC_017372:c923992-923726 [Helicobacter pylori India7]
MLKIKHHILYKKDFKKLVKNGFDDSVLNEVILTLRKKEPLPPQFQDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHSDLF

Download         Length: 267 bp

>T26762 NC_017372:c923992-923726 [Helicobacter pylori India7]
ATGCTGAAAATTAAGCACCATATCCTTTACAAAAAAGATTTTAAAAAACTTGTTAAAAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGAAAGAACCATTACCCCCACAATTTCAAGATCATGCCTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCCGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTGATTTTGTTAAGA
CTAGGCAGTCATAGCGATCTGTTTTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12334.17 Da        Isoelectric Point: 10.1909

>AT26762 WP_001134046.1 NC_017372:c923648-923337 [Helicobacter pylori India7]
MPNTTAEKDYTKYSQRQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKVLHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Download         Length: 312 bp

>AT26762 NC_017372:c923648-923337 [Helicobacter pylori India7]
ATGCCTAACACCACCGCAGAAAAAGACTACACAAAATACAGCCAAAGACAGCTTTTTAATTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAACAAAGAATTAAAAAAGCGCTCCAATTTAAAG
TGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGATACCAAGAACCAC
CTTTGTTTTAAAAGTGTAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E8QGL5

Antitoxin

Source ID Structure
AlphaFold DB E8QGL4

References