267618

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1219639..1220555 Replicon chromosome
Accession NZ_CP116011
Organism Bacillus amyloliquefaciens strain SRCM124317

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7U5AVM4
Locus tag PF976_RS06515 Protein ID WP_013351967.1
Coordinates 1219809..1220555 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag PF976_RS06510 Protein ID WP_003154807.1
Coordinates 1219639..1219809 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF976_RS06470 (1214780) 1214780..1216543 + 1764 WP_014470496.1 hypothetical protein -
PF976_RS06475 (1216555) 1216555..1216881 + 327 WP_014470495.1 XkdW family protein -
PF976_RS06480 (1216881) 1216881..1217045 + 165 WP_014470494.1 XkdX family protein -
PF976_RS06485 (1217100) 1217100..1217897 + 798 WP_014470493.1 hypothetical protein -
PF976_RS06490 (1217951) 1217951..1218214 + 264 WP_013351964.1 hemolysin XhlA family protein -
PF976_RS06495 (1218228) 1218228..1218491 + 264 WP_014470492.1 phage holin -
PF976_RS06500 (1218505) 1218505..1219383 + 879 WP_014470491.1 N-acetylmuramoyl-L-alanine amidase -
PF976_RS06505 (1219417) 1219417..1219542 - 126 WP_003154809.1 hypothetical protein -
PF976_RS06510 (1219639) 1219639..1219809 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
PF976_RS06515 (1219809) 1219809..1220555 - 747 WP_013351967.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PF976_RS06520 (1220663) 1220663..1221661 - 999 WP_013351968.1 inorganic phosphate transporter -
PF976_RS06525 (1221674) 1221674..1222291 - 618 WP_003154804.1 DUF47 domain-containing protein -
PF976_RS06530 (1222576) 1222576..1223892 - 1317 WP_013351969.1 amino acid permease -
PF976_RS06535 (1224216) 1224216..1225166 + 951 WP_013351970.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29054.53 Da        Isoelectric Point: 4.6839

>T267618 WP_013351967.1 NZ_CP116011:c1220555-1219809 [Bacillus amyloliquefaciens]
MLLFYQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRQYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT267618 WP_003154807.1 NZ_CP116011:c1219809-1219639 [Bacillus amyloliquefaciens]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U5AVM4

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References