267615

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 2776992..2777909 Replicon chromosome
Accession NZ_CP116010
Organism Bacillus velezensis strain SRCM123815

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag PF975_RS13315 Protein ID WP_007407256.1
Coordinates 2776992..2777738 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2C3Z8
Locus tag PF975_RS13320 Protein ID WP_014417527.1
Coordinates 2777739..2777909 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF975_RS13295 (PF975_13295) 2772383..2773333 - 951 WP_014417529.1 ring-cleaving dioxygenase -
PF975_RS13300 (PF975_13300) 2773655..2774971 + 1317 WP_007610842.1 amino acid permease -
PF975_RS13305 (PF975_13305) 2775257..2775874 + 618 WP_003154804.1 DUF47 domain-containing protein -
PF975_RS13310 (PF975_13310) 2775887..2776885 + 999 WP_003154805.1 inorganic phosphate transporter -
PF975_RS13315 (PF975_13315) 2776992..2777738 + 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PF975_RS13320 (PF975_13320) 2777739..2777909 + 171 WP_014417527.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
PF975_RS13325 (PF975_13325) 2778006..2778131 + 126 WP_003154809.1 hypothetical protein -
PF975_RS13330 (PF975_13330) 2778166..2779044 - 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
PF975_RS13335 (PF975_13335) 2779058..2779321 - 264 WP_003154813.1 phage holin -
PF975_RS13340 (PF975_13340) 2779335..2779598 - 264 WP_003154815.1 hemolysin XhlA family protein -
PF975_RS13345 (PF975_13345) 2779650..2780411 - 762 WP_014417526.1 hypothetical protein -
PF975_RS13350 (PF975_13350) 2780468..2780665 - 198 WP_007610833.1 XkdX family protein -
PF975_RS13355 (PF975_13355) 2780670..2781041 - 372 WP_022553475.1 XkdW family protein -
PF975_RS13360 (PF975_13360) 2781054..2781416 - 363 WP_254912362.1 hypothetical protein -
PF975_RS13365 (PF975_13365) 2781527..2782078 - 552 Protein_2634 terminase -
PF975_RS13370 (PF975_13370) 2782191..2782703 - 513 WP_012117362.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T267615 WP_007407256.1 NZ_CP116010:2776992-2777738 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.78 Da        Isoelectric Point: 10.9951

>AT267615 WP_014417527.1 NZ_CP116010:2777739-2777909 [Bacillus velezensis]
MEQAFQNGQPEKRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2C3Z8

References