Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 1065175..1065587 Replicon chromosome
Accession NZ_CP116007
Organism Pseudoxanthomonas mexicana strain DMF-5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PE064_RS05185 Protein ID WP_271250895.1
Coordinates 1065393..1065587 (-) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PE064_RS05180 Protein ID WP_271250894.1
Coordinates 1065175..1065387 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PE064_RS05155 (PE064_05155) 1061221..1061892 + 672 WP_187574066.1 Fe2+-dependent dioxygenase -
PE064_RS05160 (PE064_05160) 1061943..1062260 - 318 WP_271250890.1 DUF3817 domain-containing protein -
PE064_RS05165 (PE064_05165) 1062451..1063359 + 909 WP_271250891.1 HNH endonuclease -
PE064_RS05170 (PE064_05170) 1063349..1063918 - 570 WP_271250892.1 transposase -
PE064_RS05175 (PE064_05175) 1064038..1065135 - 1098 WP_271250893.1 crosslink repair DNA glycosylase YcaQ family protein -
PE064_RS05180 (PE064_05180) 1065175..1065387 - 213 WP_271250894.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PE064_RS05185 (PE064_05185) 1065393..1065587 - 195 WP_271250895.1 type II toxin-antitoxin system HicA family toxin Toxin
PE064_RS05190 (PE064_05190) 1065678..1068371 - 2694 WP_271250896.1 pyruvate dehydrogenase (acetyl-transferring), homodimeric type -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 6854.93 Da        Isoelectric Point: 11.6952

>T267613 WP_271250895.1 NZ_CP116007:c1065587-1065393 [Pseudoxanthomonas mexicana]
VPPKIRDVLQQLKDAGWQQVGQTGSRRQFKHPTLPGRVTVAGKPGDDVAPGTLGSILKQAGIKR

Download         Length: 195 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7316.36 Da        Isoelectric Point: 4.1511

>AT267613 WP_271250894.1 NZ_CP116007:c1065387-1065175 [Pseudoxanthomonas mexicana]
MRYAIVIEQAGGNYSAYVPDLPGCVATGATKAEVEALIHDAIALHLAGMREDGLAIPMPSSQVEYIDVAA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References